Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE Data on the efficacy of intercellular adhesion molecule-1 antisense oligonucleotide alicaforsen in ulcerative colitis (UC) is inconsistent. 29207381 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 AlteredExpression disease BEFREE H&E staining, SEM, and VG staining showed that Garidisan repaired damaged intestinal mucosa and significantly reduced expression of ICAM-1 and CD105 in regenerated tissues of UC rats. 28928792 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE This meta-analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. 25942347 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE Although such interactions may aid in clearance of invading microorganisms by promoting PMN recruitment, engagement of ICAM-1 under pathologic conditions would increase accumulation of epithelial-associated PMN, thus contributing to mucosal injury as observed in conditions, including ulcerative colitis. 24345805 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease RGD We found an increase in the levels of inflammatory markers from serum (tumor necrosis factor-α, IL-1β, IL-6 and the acute phase protein C-reactive protein) and substantia nigra (tumor necrosis factor-α, IL-1β, IL-6, inducible nitric oxide synthase, intercellular adhesion molecule-1, microglial and astroglial populations) of rats with UC, as well as an alteration of the blood-brain barrier permeability and the loss of dopaminergic neurons. 20584104 2010
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 AlteredExpression disease BEFREE Down-regulation of protein and mRNA expression of IL-8 and ICAM-1 in colon tissue of ulcerative colitis patients by partition-herb moxibustion. 19083096 2009
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 AlteredExpression disease BEFREE The aim of this study was to assess the ICAM-1 expression in human colonic tissue representing UC, Crohn's disease (CD), adenomas, and adenocarcinomas, with special attention to the epithelium. 16497620 2006
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE These findings suggest that the polymorphisms observed in the NOD2/CARD15, NOD1/CARD4, and ICAM-1 genes are not genetic susceptibility factors for Crohn's disease or ulcerative colitis in Turkey. 16741608 2006
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease LHGDN This review discusses the results from studies on the expression of ICAM-1 in colonic tissue from patients with UC. 16158332 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease LHGDN Increased adhesiveness of circulating leukocytes seems to be involved in the pathogenesis of UC, and ICAM-1 is suggested to be a part of this phenomenon. 15550998 2004
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease CTD_human The results showed that NF-kappaB DNA binding activity, mRNA and protein expression of ICAM-1 and VCAM-1 were increased significantly in patients with UC, compared with normal control (P<0.05). 15553846 2004
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Two candidate genes (DDXL and ICAM-1) within the IBD6 locus were examined in a case/control study with a total of 228 CD and 243 ulcerative colitis (UC) patients and 407 healthy controls. 15290909 2004
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Ulcerative colitis and Crohn's disease are associated with polymorphisms of the ICAM-1 gene, which might therefore represent a functional candidate gene. 11726228 2001
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Because the codon 241 polymorphism is in a functionally important domain III of ICAM-1, we may have identified an actual responsible genetic variation for genetically heterogeneous subsets of both UC and CD. 7615193 1995