Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE Compared with that in the DSS group, FMT ameliorated the severity of inflammation due to ulcerative colitis in mice, which was accompanied by a significantly decreased MPO activity, reduced levels of TNF-α and IL-1β, and an increased level of IL-10 in colon tissue (all P<0.05). 30906449 2019
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE The results indicated that treatment with EVO ameliorated DSS-induced UC mice body weight loss, disease activity index (DAI), colon length shortening, colonic pathological damage, and myeloperoxidase (MPO) activity. 30554117 2019
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS. 30797423 2019
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE Meanwhile, MAP induced high specific antibody titers in vivo, reduced the DAI score, serum MPO activity, colorectal lymph node colony count, ultrastructural injuries, colon tissue histological index score and MPO activity in UC mice, while increasing the expression levels of occludin, claudin1 and ZO1 in colon tissues. 31524230 2019
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE The results showed that treatment with Lico A significantly reduced the colon length, histological damage scores, and colonic myeloperoxidase (MPO) activity in a dose-dependent manner as compared to the UC control group. 29710547 2018
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE Biochemical analysis was carried out for asserting the levels of tissue myeloperoxidase (MPO) accumulation, SOD concentrations, reduced GSH and lipid peroxidation in UC induced and treated animals. 29530609 2018
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 Biomarker disease BEFREE Microscopic images of tissue sections of colon extracted from UC model mice demonstrated that HSA NPs and MPO were both localized in the colon, and this specific interaction between HSA NPs and MPO would be involved the in the therapeutic effect in vivo. 29407223 2018
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE After orally administrating a GCZX-pill to UC rats for 14 days, the results of the inflammation evaluation, such as disease activity index (DAI), macroscopic score (MS), myeloperoxidase (MPO) activity, and other methods, suggested that the GCZX-pill showed remarkable anti-inflammatory results in UC rats. 28845184 2017
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 Biomarker disease BEFREE MSE decreased colonic secretions of pro-inflammatory keratinocyte-derived cytokine (KC), tumor necrosis factor (TNF)-α, nitric oxide (NO), and myeloperoxidase (MPO) in acute and chronic UC; reduced fecal lipocalin-2 in acute UC; downregulated gene expression of pro-inflammatory interleukin (IL)-1, IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) in acute UC; upregulated expression of claudin-1 and ZO-1 in acute and chronic UC; and upregulated GSTP1, an Nrf2-mediated phase II detoxifying enzyme, in chronic UC. 28922365 2017
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE Disease activity index (DAI), histological damage score (HDS) and myeloperoxidase (MPO) activity were used to evaluate the severity of UC. 28781623 2017
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 Biomarker disease CTD_human Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats. 24055189 2013
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 Biomarker disease BEFREE The epigenetic/genetic associations related to elevated MPO staining in UC-CRC may offer new methods for risk stratification and adjunctive screening tools. 21425209 2012
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 Biomarker disease CTD_human Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine. 22119283 2012
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 AlteredExpression disease BEFREE Inflammatory cells' infiltration and MPO activity increased significantly in the untreated UC, but was significantly lower in the treated UC groups 3 and 4 (P < 0.05). 21221801 2011
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.400 Biomarker disease CTD_human Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis. 20380826 2010