| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.640 | GeneticVariation | disease | GWASCAT | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. | 28067908 | 2017 | ||||
|
0.640 | Biomarker | disease | BEFREE | CCL20 and CCR6 mRNA abundances were increased during active inflammation (CCL20 5.4-fold in ulcerative colitis and 4.2-fold in Crohn's disease; CCR6 1.8 and 2.0, respectively). | 26536229 | 2015 | ||||
|
0.640 | Biomarker | disease | BEFREE | CCL20 may play a significant role in local damage and pathological changes in UC and may serve as a potential target for therapy. | 23008075 | 2012 | ||||
|
0.640 | Therapeutic | disease | RGD | The results showed that baicalin simultaneously down-regulated the expression of MIF, the quantity of MΦs and the amount of MΦ-related cytokines, including macrophage chemotactic factor-1 (MCP-1, CCL2) and macrophage inflammatory protein-3α (MIP-3α, CCL20), in rats with UC. | 21887805 | 2012 | ||||
|
0.640 | Biomarker | disease | BEFREE | The present study assessed the mRNA expression levels of Th17 effector cytokines (IL17A, IL17F, IL21, IL22 and IL26) and genes involved in differentiation (IL6, IL1B, TGFB1, IL23A and STAT3) and recruitment of Th17 cells (CCR6 and CCL20) by quantitative real-time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects, 26 patients with Crohn's disease (CD) and 12 patients with ulcerative colitis (UC). | 21144017 | 2010 | ||||
|
0.640 | Biomarker | disease | CTD_human | Supporting these findings, results from a 3-month follow-up study revealed that the UC groups treated with 5-aminosalicylic acid and glucocorticoid exhibited dramatic decreases of CCL20 mRNA in PBMCs, accompanied by ameliorated disease states. | 16306769 | 2005 | ||||
|
0.640 | AlteredExpression | disease | BEFREE | CCL20 mRNA and protein were severalfold increased in involved CD and UC but not in non-IBD colitis. | 14997037 | 2004 |