Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE However, the molecular mechanisms of TL1A in UC development are poorly understood. 31176785 2019
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis. 29873318 2018
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE The aim of this study was to investigate the association of TNFSF15 gene polymorphisms located in the promoter region, including rs6478108 (G/A -9706) and rs3810936 (G/A -15524) in Iranian patients with UC. 30556168 2018
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10). 26398853 2016
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects. 26072972 2015
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE Moreover, we found individual disease risk loci: TNFSF15 and TNFα to CD and HLA-B*5201, and NFKBIL1 to UC. 23942620 2014
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE The TNFSF15 gene has been associated with other inflammatory diseases affecting the colon such as medically refractory ulcerative colitis (UC), aggressive Crohn's disease (CD), and pouchitis after restorative proctocolectomy. 24814505 2014
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE Focusing on TNFSF15 instead of NOD2, we set out to evaluate whether combining serologic and genetic markers could distinguish between Crohn’s disease (CD) and ulcerative colitis (UC), and whether they could be used to stratify the disease behavior of Taiwanese CD patients. 24783249 2014
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE We examined the association of seven single nucleotide polymorphisms (SNP) in the TNFSF15 gene with Crohn's disease (CD) and ulcerative colitis (UC) in the Indian population. 25501099 2014
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility. 25028192 2014
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 AlteredExpression disease BEFREE No correlation was found between the genotype and serum levels of IL-12p40 or TL1A in UC patients. 24382939 2013
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE Our data suggest that neither TNFSF15 nor IL23R variants contribute to UC susceptibility in Koreans. 21228792 2011
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease GWASCAT Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633 2011
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE Association with TNFSF15 and pediatric UC was also reported. 21818367 2011
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease GWASDB Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633 2011
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease BEFREE TL1A/DcR3-mediated pathways may participate in the pathogenesis of UC. 20675196 2010
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 Biomarker disease CTD_human Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 20228799 2010
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE Comparison of the MR-UC subjects with healthy controls confirmed the contribution of the major histocompatibility complex to severe UC (peak association: rs17207986, P = 1.4 × 10(-16)) and provided genome-wide suggestive association at the TNFSF15 (TL1A) locus (peak association: rs11554257, P = 1.4 × 10(-6)). 20848476 2010
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE Analysis by the modified genotype relative risk test (mGRR) indicated that the risk allele of TNFSF15 is dominant for CD, but is recessive for UC. 20367632 2010
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. 20176734 2010
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 AlteredExpression disease BEFREE TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD). 19262684 2009
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease BEFREE Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn's disease and partly also to ulcerative colitis. 19592695 2009
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.500 GeneticVariation disease LHGDN Of further interest, the haplotype frequency was in the opposite direction in our Jewish case-control panels (both CD and UC), leading us to conclude 1) that TNFSF15 is indeed an IBD susceptibility gene, and 2) the disease susceptibility is ethnic-specific. 17663424 2007