Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE In Apc(Min) (/+) mice, constitutive CpG methylation of the Fxrα3/4 promoter was linked to reduced (60-90%) baseline Fxr, Ibabp, and Shp and increased Cox-2 expression in apparently normal adjacent mucosa and colon tumors. 26609171 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Moreover, CCL2 antagonists decreased intracolonic macrophage infiltration and COX-2 expression, attenuated neovascularization, and eventually reduced the numbers and size of colon tumors, even when given after multiple colon tumors have developed. 19773434 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE These results reveal that the JB oil acted as a chemopreventive dietary agent, inhibiting cell proliferation and COX-2 expression and inducing apoptosis, resulting in a significant reduction in colon tumor formation. 31617778 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE To further explore how cancer cells exploit the progrowth actions of prostaglandins while suppressing the proapoptotic actions of intracellular arachidonic acid, we determined the cytoplasmic phospholipase A(2) (cPLA(2)) and COX-2 expression levels in a panel of human colon tumors by immunohistochemistry. 15788676 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples. 21081470 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE We reliably detected germline SNPs and discovered a colon tumor specific nonsense mutation in APC, a gene causally implicated in colorectal cancer. 18849522 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and acts in the colon as a required physiologic antagonist of the prostaglandin-synthesizing activity of the cyclooxygenase 2 (COX-2) oncogene. 16880406 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.600 PosttranslationalModification group BEFREE Our results support the view that malignant progression is a consequence of more than one genetic change and suggest that inactivation of APC and DCC genes plays a role in a multistep process of colon tumor progression. 10090594 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. 21459756 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE Whereas some patients showed a single epigenotype in all tumors throughout the colon, tumors with two distinct epigenotypes developed within a family with the same APC mutation or even within one patient. 27563825 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE We tested the hypothesis that abnormal expression of prostaglandin H synthase 2 (PHS-2), which can be induced by oncogenes and tumor promoters, occurs during colon carcinogenesis by examining its level in colon tumors. 8643486 1996
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker group BEFREE The different pathways observed and their distribution can be summarized as follows: (a) K-ras mutations were more commonly detected in colon than in rectum; (b) the number of mutations detected was significantly higher in colon than in rectal tumors; and (c) a mutational pattern restricted to the APC gene was more common in rectal than in colon tumors. 15217933 2004
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE Recent evidence suggests that the beta-catenin gene (CTNNB1) acts as an oncogene, and some human colon tumors with an intact APC gene have activating mutations in CTNNB1. 10204808 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors. 15733272 2005
Entrez Id: 324
Gene Symbol: APC
APC
0.600 AlteredExpression group BEFREE In female APC(Min/+) mice, both dose levels of Frondanol A5 suppressed colon tumor multiplicities up to 80% (P < 0.0001). 25657017 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE Using NGS, the following mutations were detected: nonsense mutations in four tumor suppressor genes [APC R1114X (molecular argument that the cancer was a primary tumor of colon), TP53 R213X, RB1 E137X and FBWX7 R393X & S282X], mutations in three receptor tyrosine kinases (RET A919V of high transforming activity, EGFR E114K and FLT3 L601I) well known as oncogenes. 28730258 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression group BEFREE We are interested in the mechanism of cyclooxygenase-2 (Cox-2) regulation in colon cancer cells because this knowledge could provide insight into colon carcinogenesis and suggest ways to suppress Cox-2 expression in colon tumors. 15713675 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE Although the cyclooxygenase-2 (COX-2) pathway of the arachidonic acid cascade has been suggested to play an important role in colon carcinogenesis, there is little information concerning the identity of phospholipase A(2) (PLA(2)) involved in the arachidonic acid release in colon tumors. 11150521 2000
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker group BEFREE This study investigated the relationship between E-cadherin and COX-2 in colon cancer cells and human colon tumors. 20046424 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE Guanine deletions at this site in the Apc gene have been found to be preferentially induced by PhIP in rat colon tumors. 19628463 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE The majority of colon tumors develop because of mutations in the tumor suppressor APC that lead to Wnt/beta-catenin signaling activation and subsequent transcription of target genes, including conductin/AXIN2. 16815967 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker group BEFREE Recently defined target genes are c-myc and cyclin D1, linking the APC gene defect to the capacity for autonomous proliferation of colon tumors. 10514384 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE We investigated the presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated with any other genetic variants; we performed deep sequence analysis of APC in at least 2 adenomas or carcinomas per patient. 27816598 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE PhIP in the diet for >43 weeks present colon tumors with specific -1G mutations within 5'-GGGA-3' sequences of the APC: gene. 11181456 2001
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation group BEFREE These results suggest the following mechanisms for the development of colon tumors in patients with familial adenomatous polyposis: (a) the heterozygous mutant/wild-type condition at the APC gene causes formation of mild or moderate adenoma; (b) the loss of the normal allele in the APC gene leads to a change from moderate to severe adenoma; (c) LOH on chromosome 17p contributes to the conversion of adenoma to intramucosal carcinoma; (d) LOH on other chromosomes, such as 18 and 22q, are involved in the progression of intramucosal carcinoma to invasive carcinoma; and (e) K-ras mutation may also affect the development of moderate to severe adenoma. 1977514 1990