Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 Biomarker group CTD_human gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. 19147571 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 Biomarker group RGD These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1. 17404573 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 AlteredExpression group BEFREE These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1. 17404573 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 Biomarker group CTD_human These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1. 17404573 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 Biomarker group LHGDN Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. 16227396 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 AlteredExpression group LHGDN Low frequency of bcl-2 expression in large non-polypoid colonic neoplasms. 15303767 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 AlteredExpression group LHGDN Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. 15314290 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 AlteredExpression group BEFREE Our results showed that: i) a significant relationship exists between apoptosis and genesis of colorectal cancer since, compared to adenomatous polyps and adjacent normal mucosa, cell death is markedly inhibited in tumors (p = 0.01); ii) during colon tumor progression, apoptosis and amplifications of c-myc/c-myb genes are inversely related; iii) Bcl-2 expression is retained in colon tumors even though at a significantly lower level with respect to adenomatous polyps. 11848471 2002
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 Biomarker group CTD_human Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. 10223192 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.560 AlteredExpression group BEFREE p53 expression and bcl-2 protein overexpression in rectosigmoid adenomas are associated with advanced histology and a high risk of synchronous advanced proximal colon neoplasm. 9672345 1998