Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group BEFREE In RAS-BRAF wild type left colon tumors, Turkish oncologists mostly use chemotherapy and anti-EGFR therapy (90.1%) for the first-line treatment, while on the right side, oncologists favored anti-VEGF therapy in combination with chemotherapy (65.5%). 30941953 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group BEFREE Our results showed that biglycan overexpression notably up-regulated the levels of VEGF in colon cancer cells, which was further confirmed by immunohistochemistry analysis in the xenograft colon tumors. 25371074 2015
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation group BEFREE After stratifying by tumor molecular subtype, SNP associations observed for colon cancer were: VEGFA rs2010963 with CIMP+ colon tumors; FLT1 rs4771249 and rs7987649 with TP53; FLT1 rs3751397, rs7337610, rs7987649, and rs9513008 and KDR rs10020464, rs11941492, and rs12498529 with MSI+ and CIMP+/KRAS2-mutated tumors. 23794399 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group BEFREE Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth. 23759331 2013
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group BEFREE Increased expression of vascular endothelial growth factor in colon tumors vs normal colon was suppressed by loss of PPAR-delta expression. 19436036 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group CTD_human Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. 18987561 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group BEFREE Both Del1-shRNA and VEGF-shRNA gene therapies exhibited anti-tumor activities and they also showed a synergistic effect in suppressing growth of colon tumors by anti-angiogenesis and anti-proliferation. 19292890 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation group LHGDN Gender-specific association between polymorphism of vascular endothelial growth factor (VEGF 936 C>T) gene and colon cancer in Korea. 18505065 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation group LHGDN Vascular endothelial growth factor polymorphisms -1154 G/A and -460 C/T are not associated with VEGF mRNA expression and susceptibility to sporadic colon cancer. 18613756 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group LHGDN Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. 18172321 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group LHGDN Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. 19020709 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group BEFREE Activation of beta-adrenoceptors and the subsequent stimulation of COX-2, PGE(2), and VEGF expression is perhaps an important mechanism in the tumorigenic action of nicotine on colon tumor growth. 17369603 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group LHGDN [Expression of MMP-2, HIF-1alpha and VEGF in colon adenoma and colon cancer]. 18172354 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation group LHGDN Gender-specific association of the VEGF -2578C > A polymorphism in Korean patients with colon cancer. 17695550 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group LHGDN Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. 16543245 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group BEFREE VEGF directly promotes colon tumor epithelial cell survival through activation of PI3K-Akt signaling. 17148604 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group LHGDN Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. 12727858 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker group LHGDN Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29. 12016145 2002
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group LHGDN Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. 11956638 2002
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression group BEFREE Although these results are consistent with the known role of wild-type p53 in down-regulating VEGF, no association was found between a mutation in p53 and VEGF or bFGF levels in all colonic neoplasms. 10547592 1999