Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Familial adenomatous polyposis (FAP) is a rare autosomal-inherited disease that highly predisposes to colorectal cancer, characterized by a diffuse duodenal and colorectal polyposis associated with various extradigestive tumors and linked to germline mutations within the APC gene. 24599579 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Detection of APC mutations in stool DNA of patients with colorectal cancer by HD-PCR. 9450908 1998
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC(Min/+) mice. 26388189 2016
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE To accurately assess the incidence of mutation of tumor suppressor genes (p53: exon 5-8; APC: mutated cluster region; NF-2 gene: all exons) in 45 colorectal carcinomas. 10705390 2000
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients. 15266213 2005
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. 21851818 2012
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE This WES study in African American patients with CRC provides insight into the identification of novel somatic mutations in APC. 25250560 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE However, the remaining 13 (37%) hypermutated CRCs lacked MLH1 silencing, contained tumours with the highest mutation rates ('ultramutated' CRCs), and exhibited higher incidences of APC and KRAS mutations, but infrequent BRAF mutations. 22899370 2013
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE In addition, we have partially transformed the HCEC 1CT line by introducing stable knockdown of wild type APC and TP53, and ectopically introducing a mutant Krasv12 and a mutant version of APC (A1309), all commonly found mutations in colorectal cancer (CRC). 25923178 2016
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE We found that BCL9 is required for efficient beta-catenin-mediated transcription in Wnt-stimulated HEK 293 cells, and in the SW480 colorectal cancer cell line whose Wnt pathway is active due to APC mutation. 18627596 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Early research efforts using patient derived CRC samples led to the discovery of several highly penetrant mutations (e.g., APC, KRAS, MMR genes) in both hereditary and sporadic CRC tumors. 26811627 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews. 11159880 2001
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE A low-penetrance susceptibility allele that is common in Jews from Eastern Europe, APC 11307K, confers a two-fold increased risk of colorectal cancer without the full expression of familial adenomatous polyposis. 16629258 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Familial adenomatous polyposis (FAP) is a colorectal cancer predisposition syndrome caused by mutations in the adenomatous polyposis coli (APC) gene. 25243319 2016
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.600 GeneticVariation disease BEFREE This hypothesis was based on the frequent involvement of the DCC gene in colorectal carcinoma and on the previously reported linkage between HNPCC and the Kidd blood group locus (JK) also on 18q. 1868434 1991
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. 15540296 2004
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. 15793634 2005
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE However, not all sporadic and familial CRCs can be explained by mutations in APC or other genes with well-established roles in CRC. 25236910 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE AXIN2 and MUTYH genes were screened for germline mutations by PCR and direct sequencing in 39 unrelated patients with multiple adenomas or colorectal cancer without evidence of APC mutation nor mismatch repair defect. 16941501 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Familial adenomatous polyposis (FAP) is an autosomal dominant form of intestinal polyposis and colorectal cancer caused by germ-line mutations in the adenomatous polyposis coli (APC) gene. 19573802 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons. 17556698 2007
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE There is increasing evidence that there exist germ-line variants of the APC gene that predispose to the development of multiple colorectal adenomas and carcinoma, but without the florid phenotype of classical FAP, and possibly with importance for colorectal cancer risk in the general population. 9724771 1998
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. 18632633 2008
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. 10490837 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatous polyposis from mutations of APC, or hereditary nonpolyposis colorectal cancer, resulting from mutations of MSH2, MLH1, MSH6, or other genes. 12595050 2003