Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Familial adenomatous polyposis (FAP) is a rare autosomal-inherited disease that highly predisposes to colorectal cancer, characterized by a diffuse duodenal and colorectal polyposis associated with various extradigestive tumors and linked to germline mutations within the APC gene. 24599579 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Detection of APC mutations in stool DNA of patients with colorectal cancer by HD-PCR. 9450908 1998
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC(Min/+) mice. 26388189 2016
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE To accurately assess the incidence of mutation of tumor suppressor genes (p53: exon 5-8; APC: mutated cluster region; NF-2 gene: all exons) in 45 colorectal carcinomas. 10705390 2000
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients. 15266213 2005
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.600 Biomarker disease BEFREE However, thus far few studies have analyzed the impact of numerical abnormalities of chromosomes 17 and 18, which carry the p53 and DCC plus SHAD4/DPC4 genes involved in colorectal cancer, on the clinical and biological behaviors of the disease. 12500293 2004
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons. 19951906 2010
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. 21851818 2012
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.600 AlteredExpression disease BEFREE Protein expression of the putative tumour-suppressor gene DCC on chromosome 18q was evaluated in a panel of 16 matched colorectal cancer and normal colonic tissue samples together with DCC mRNA expression and allelic deletions (loss of heterozygosity, LOH). 9484816 1998
Entrez Id: 324
Gene Symbol: APC
APC
0.600 PosttranslationalModification disease BEFREE Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. 9096643 1997
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE We also hypothesize that its disruption in human CRCs is likely a mere result of its close proximity to APC in the human genome. 20707908 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE This WES study in African American patients with CRC provides insight into the identification of novel somatic mutations in APC. 25250560 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. 25025473 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE The erosion of telomeres, mainly because of cell proliferation, may be accelerated by specific alterations in the genes involved in CRC, such as APC and MSH2. 24616570 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE However, the remaining 13 (37%) hypermutated CRCs lacked MLH1 silencing, contained tumours with the highest mutation rates ('ultramutated' CRCs), and exhibited higher incidences of APC and KRAS mutations, but infrequent BRAF mutations. 22899370 2013
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE In addition, we have partially transformed the HCEC 1CT line by introducing stable knockdown of wild type APC and TP53, and ectopically introducing a mutant Krasv12 and a mutant version of APC (A1309), all commonly found mutations in colorectal cancer (CRC). 25923178 2016
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE We found that BCL9 is required for efficient beta-catenin-mediated transcription in Wnt-stimulated HEK 293 cells, and in the SW480 colorectal cancer cell line whose Wnt pathway is active due to APC mutation. 18627596 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Early research efforts using patient derived CRC samples led to the discovery of several highly penetrant mutations (e.g., APC, KRAS, MMR genes) in both hereditary and sporadic CRC tumors. 26811627 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews. 11159880 2001
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE A low-penetrance susceptibility allele that is common in Jews from Eastern Europe, APC 11307K, confers a two-fold increased risk of colorectal cancer without the full expression of familial adenomatous polyposis. 16629258 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. 8318422 1993
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Familial adenomatous polyposis (FAP) is a colorectal cancer predisposition syndrome caused by mutations in the adenomatous polyposis coli (APC) gene. 25243319 2016
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.600 GeneticVariation disease BEFREE This hypothesis was based on the frequent involvement of the DCC gene in colorectal carcinoma and on the previously reported linkage between HNPCC and the Kidd blood group locus (JK) also on 18q. 1868434 1991
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. 15540296 2004
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. 15793634 2005