Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 84639
Gene Symbol: IL1F10
IL1F10
0.010 Biomarker disease BEFREE By sub-group analysis, AUC of IL-38 for the diagnosis of CRC was higher in poorly differentiated, right-sided CRC or tumour size > 5 cm (all AUC > 0.9). 31786620 2020
Entrez Id: 25821
Gene Symbol: MTO1
MTO1
0.010 Biomarker disease BEFREE In this review, we discuss the formation, classification, and biological functions of circRNAs, especially their molecular diagnostic values in common cancers, including gastric cancer (hsa_circ_002059, circ_LARP4, hsa_circ_0000190, hsa_circ_0000096, circ-SFMBT2, and circ_PVT1), hepatocellular carcinoma (circ_104075, circRNA_100338, circ_MTO1, and circZKSCAN1), colorectal cancer (hsa_circ_0136666 and hsa_circ_0000523), lung cancer (hsa_circ_0006427, circ_100876, and circ_ABCB10), breast cancer (hsa_circ_0089105, circAGFG1, and circEPSTI1), bladder cancer (circFNDC3B and circTFRC), and esophageal squamous cell carcinoma (circ_100876 and circ-DLG1). 31556152 2020
Entrez Id: 58476
Gene Symbol: TP53INP2
TP53INP2
0.010 Biomarker disease BEFREE When test results for BMP3 and NDRG4 were combined, the DOR of CRC detection was 98.36, which was higher than that for BMP3 and NDRG4 separately. 31097151 2020
Entrez Id: 373863
Gene Symbol: DND1
DND1
0.010 AlteredExpression disease BEFREE Investigation of DND1 expression in CRC cell lines showed up to 5.3-fold upregulation of DND1. 31646794 2020
Entrez Id: 54206
Gene Symbol: ERRFI1
ERRFI1
0.010 AlteredExpression disease BEFREE Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation. 31313286 2020
Entrez Id: 54664
Gene Symbol: TMEM106B
TMEM106B
0.010 AlteredExpression disease BEFREE Rescue assays verified that TMEM106B overexpression recovered the effects of MAGI2-AS3 inhibition on cell apoptosis, proliferation, and migration in CRC. 31709544 2020
Entrez Id: 644192
Gene Symbol: NR2F2-AS1
NR2F2-AS1
0.010 AlteredExpression disease BEFREE We found that NR2F2-AS1 and cyclin-dependent kinase 6 (CDK6) were both upregulated in CRC and were positively correlated. 31432342 2020
Entrez Id: 55753
Gene Symbol: OGDHL
OGDHL
0.010 Biomarker disease BEFREE In the present study, we investigated methylation status of OGDHL gene promoter in patients with colorectal cancer and evaluated its potential as a diagnostic biomarker. 30904169 2020
Entrez Id: 645212
Gene Symbol: EIF3J-DT
EIF3J-DT
0.010 AlteredExpression disease BEFREE Results showed that EIF3J-AS1 was upregulated in CRC tissues and cell lines, indicating poor prognosis of CRC patients. 31709617 2020
Entrez Id: 3210
Gene Symbol: HOXB@
HOXB@
0.010 Biomarker disease BEFREE Herein, we reported that SE-associated HOXB gene cluster represented a common feature of colorectal cancer (CRC) cell lines and multiple HOXB genes within this cluster were overexpressed in CRC. 31591481 2020
Entrez Id: 128439
Gene Symbol: SNHG11
SNHG11
0.010 Biomarker disease BEFREE The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). 31633800 2020
Entrez Id: 11340
Gene Symbol: EXOSC8
EXOSC8
0.010 Biomarker disease BEFREE Finally, functional experiments confirmed the oncogenic roles of EXOSC8 in colorectal carcinoma. 31548613 2020
Entrez Id: 7138
Gene Symbol: TNNT1
TNNT1
0.010 AlteredExpression disease BEFREE Immunohistochemical staining and real-time PCR were used to compare the expression level of TNNT1 in CRC tissues and adjacent tissues. 31830337 2020
Entrez Id: 400657
Gene Symbol: LINC00909
LINC00909
0.010 Biomarker disease BEFREE The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). 31633800 2020
Entrez Id: 100506866
Gene Symbol: TTN-AS1
TTN-AS1
0.010 AlteredExpression disease BEFREE TTN-AS1 upregulation was observed both in CRC tissues and cell lines. 31610194 2020
Entrez Id: 100313824
Gene Symbol: MIR663B
MIR663B
0.010 Biomarker disease BEFREE In conclusion, the current study revealed a pivotal role of miR-663b in the progression of colorectal cancer. 31758392 2020
Entrez Id: 1303
Gene Symbol: COL12A1
COL12A1
0.010 Biomarker disease BEFREE Through further experimental verification, we found that the AS of six genes showed significant differences between the tumor sample and the normal sample, and AS of <i>TCF7, COL12A1, GK,</i> and <i>UBA1</i> can be used as new potential biomarkers in CRC. 31808724 2020
Entrez Id: 9111
Gene Symbol: NMI
NMI
0.010 AlteredExpression disease BEFREE Moreover, the proliferation of CRC cells was suppressed significantly after we silenced the expression of NMI, while overexpression of NMI promoted CRC cell proliferation. 31230364 2020
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
0.010 Biomarker disease BEFREE CD32A<sup>131R</sup> -CR T cells combined with the mAb 8.26 (anti-CD32) and CD16<sup>158F</sup> -CR T cells combined with the mAb 3g8 (anti-CD16) eliminated colorectal carcinoma (CRC), HCT116<sup>FcγR+</sup> cells, in a reverse ADCC assay in vitro. 31479522 2020
Entrez Id: 155465
Gene Symbol: AGR3
AGR3
0.010 AlteredExpression disease BEFREE In our study, we find that AGR3 is highly expressed in CRC and associated with poor prognosis. 31526829 2020
Entrez Id: 574461
Gene Symbol: MIR520E
MIR520E
0.010 Biomarker disease BEFREE In this study, we determined the specific role of miR-520e in colorectal cancer. 31574178 2020
Entrez Id: 146198
Gene Symbol: ZFP90
ZFP90
0.010 Biomarker disease BEFREE Taken together, these findings reveal a risk SNP-mediated long-range regulation on the NFATC2-ZFP90-BMP4 pathway underlying the initiation of CRC. 31641208 2020
Entrez Id: 102465141
Gene Symbol: MIR6165
MIR6165
0.010 Biomarker disease BEFREE Taken together, the results of our study suggest a tumor suppressive role of miR-6165 in colorectal cancer, which seems to take place by regulating IGF-1R gene expression. 31702994 2020
Entrez Id: 23368
Gene Symbol: PPP1R13B
PPP1R13B
0.010 Biomarker disease BEFREE DC-SIGN activation recruited Lyn and p85 to form the DC-SIGN-Lyn-p85 complex, which promoted CRC metastasis by increasing PI3K/Akt/β-catenin signaling in tyrosine kinase Lyn-dependent manner. 31217502 2020
Entrez Id: 126282
Gene Symbol: TNFAIP8L1
TNFAIP8L1
0.010 Biomarker disease BEFREE TIPE1 Impairs Stemness Maintenance in Colorectal Cancer Through Directly Targeting β-catenin. 31111874 2020