Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE The erosion of telomeres, mainly because of cell proliferation, may be accelerated by specific alterations in the genes involved in CRC, such as APC and MSH2. 24616570 2015
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.600 Biomarker disease BEFREE Bisulfite-treated DNA samples from 73 eligible patients were amplified by quantitative methylation-specific polymerase chain reaction (QMSP) targeting 6 genes (deleted in colorectal cancer [DCC], endothelin receptor type B [EDNRB], homeobox protein A9 [HOXA9], kinesin family member 1A [KIF1A], nidogen-2 [NID2], and N-methyl D-aspartate receptor subtype 2B [NR2B]). 25773145 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE We hypothesized that germline variants in these genes may influence CRC risk, similar to APC, which is causing CRC through germline and somatic mutations. 24706189 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Methylation levels were correlated with MSI and CIMP statuses and known mutations within the APC, BRAF and KRAS genes in 264 matched samples representing the progression from normal to pre-invasive adenoma to colorectal carcinoma. 25432628 2015
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.600 GeneticVariation disease BEFREE Combined analysis of data obtained from individuals of either Kazakh or Russian decent showed a significant association with increased CRC risk in the following genotypes: DCC (32008376G/G and G/A versus A/A; OR = 3.45, 95 % confidence interval (95 %CI) = 1.75-6.81, χ (2) = 14.07, p < 0.0002), MLH1 (-93G/G versus G/A and A/A; OR = 1.45, 95 %CI = 1.02-2.07, χ (2) = 4.21, p < 0.04), TP53 (Pro72Pro; OR = 3.80, 95 %CI = 2.46-5.88, χ (2) = 61.27, p < 0.0001), combination GSTT1 deletions with heterozygotes versus normal homozygotes (OR = 1.43, 95 %CI = 1.00-2.04, χ (2) = 3.90, p < 0.05), and GSTM1 deletions (OR = 1.83, 95 %CI = 1.28-2.63, χ (2) = 11.04, p < .001). 25249451 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Loss-of-function mutations in APC are commonly found in CRC, leading to inappropriate activation of canonical Wnt signaling. 25500543 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Germline mutation in the adenomatous polyposis coli (APC) gene causes the majority (80%) of familial adenomatous polyposis (FAP), an autosomal dominantly inherited form of colorectal cancer (CRC). 24169521 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE To uncover novel causative genes in patients with unexplained adenomatous polyposis, a model disease for colorectal cancer, we performed a genome-wide analysis of germline copy number variants (CNV) in a large, well characterized APC and MUTYH mutation negative patient cohort followed by a targeted next generation sequencing (NGS) approach. 25219767 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Somatic mutations were detected in 40% of CRC-related genes, and we observed a striking 100% genetic concordance between primary and multiple secondary sites for APC, KRAS, FBXW7, PIK3CA, BRAF, SMAD4, and ACVR2A. 25786087 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Understanding the type of APC mutation should better predict 5-FU resistance in CRC than simply characterizing APC status as wild-type or mutant. 25460919 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE APC(Min/+)-Cdx2 mutants recapitulated several aspects of human colorectal cancer, including an invasive phenotype. 25320087 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Mutations of the adenomatous polyposis coli (APC) gene are considered as the initiating step of transformation in familial and sporadic CRCs. 25301724 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE In FAP patients, the CRC risk score did not differ significantly from the controls, as we expected given the overwhelming effect of pathogenic germline APC variants on the phenotype of these cases. 24801760 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 AlteredExpression disease BEFREE Our results showed increased Dnmt3a expression in colon adenomas of APC((Min/+)) mice and human colorectal cancer samples when compared with control tissue. 24837369 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE CRC is a very heterogeneous disease, and with a few exceptions (APC, p53, KRAS), most of the genes involved in CRC are observed in a small percentage of cases. 24944469 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Familial adenomatous polyposis (FAP) is a rare autosomal-inherited disease that highly predisposes to colorectal cancer, characterized by a diffuse duodenal and colorectal polyposis associated with various extradigestive tumors and linked to germline mutations within the APC gene. 24599579 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE However, not all sporadic and familial CRCs can be explained by mutations in APC or other genes with well-established roles in CRC. 25236910 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 AlteredExpression disease BEFREE However, the majority of sporadic forms of colorectal cancer are characterized by inactivation of the tumor suppressor gene APC due to loss of heterozygosity (LOH), resulting in deregulation of the protein β-catenin. 24623448 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Colorectal adenomatous polyposis is associated with a high risk of colorectal cancer (CRC) and is frequently caused by germline mutations in APC or MUTYH. 24253443 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC. 23983135 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APC(Min)/CD24 double knockout transgenic mice. 24500912 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Two genetic instability pathways viz. chromosomal instability, driven primarily by APC mutation induced deregulated Wnt signaling, and microsatellite instability (MSI) caused by mismatch repair (MMR) inactivation, together account for >90% of late-onset colorectal cancer (CRC). 23168910 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE In a heavily pretreated patient with advanced colorectal cancer carrying mutations in APC and KRAS genes, we show an early metabolic response and enhanced NK cell activity to monotherapy with lenalidomide. 24351336 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 GeneticVariation disease BEFREE Originally, colorectal cancer (CRC) tumorigenesis was understood as a multistep process that involved accumulation of tumor suppressor genes and oncogenes mutations, such as APC, TP53 and KRAS. 25051912 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.600 Biomarker disease BEFREE Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells. 24086117 2014