Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE The expression of cytochrome P450 2C19 (CYP2C19) and ATP-binding cassette, sub-family B member 1 (ABCB1) were significantly lower in the EREC group (6/15) compared to the NREC group (9/15) in colorectal cancer with metachronous liver metastasis and with serum CEA >5 ng/ml. 27127120 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE We investigated the consequences of ABCB1/MDR1 loss-of-function in a common murine model for CAC (AOM/DSS). 28686677 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE Further studies on herbal medicines with demonstrated effects against P-gp overexpression will aid in improving the efficacy of chemotherapy in CRC. 30158992 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer. 19192650 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE CRC risk associated with ever MHT use as well as with duration was significantly modified by rs1202168 in the transporter gene ABCB1 (P interaction=0.04). 21490239 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Combined PC and CRC signature or "combined cancer signature" was derived to differentiate either CRC and PC from controls (MDR1, SRBC, VHL, MUC2, RB1, SYK and GPC3) AUC = 0.8177, Sens = 0.6316 Spec = 0.840. 24288256 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Our results suggest that the ABC transporters P-glycoprotein/multidrug resistance 1 and BRCP, in cooperation with IL-10, are involved in the biological mechanism underlying the protective effect of fiber intake in relation to CRC. 26109419 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE P-glycoprotein is positively correlated with p53 protein accumulation in human colorectal cancers. 9330605 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE JJR reversed multidrug resistance and enhanced the sensitivity to chemotherapy, which could be attributed to the down-regulation of COX-2 in MDR1/P-gp-mediated MDR colorectal cancer after chemotherapy. 23543356 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE P-glycoprotein (P-gp) is a 170 kDa transmembrane glycoprotein which plays a significant role in modulating pleomorphic or multiple drug resistance (MDR) in a wide variety of human cancers like renal and colorectal carcinoma. 10630353 1999
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE In the present study, we showed that PIK3CA and PIK3CB are upregulated in CRCs and positively correlated with MDR-1, LRP, and GST-π. 26747178 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. 11323103 2001
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE In the present study, 146 Bulgarian patients with sporadic colorectal cancer and 160 healthy Bulgarian volunteers were evaluated for the two polymorphisms in MDR1. 17674045 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease UNIPROT
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU. 30741544 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells. 31487863 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer. 25691056 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE Genotyping of SNPs in the ABCB1 gene prior to chemotherapy administration could help reduce adverse reactions in colorectal cancer patients. 21142915 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 PosttranslationalModification disease BEFREE Wide-type p53 gene has a remarkable reversal activity for the high expression of MDR1 gene in colorectal cancers. 15222051 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE While expression levels of Nrf2 and ABCB1 (P-gp) were markedly higher in both mRNA and protein levels in CRC biopsies (p < 0.01), Keap1 expression level was significantly lower in these samples (p < 0.05). 29793178 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE Results revealed that the protein and messenger RNA expressions of Beclin1, LC3, mTOR, Raptor, Rictor, and MDR-1 in CRC are significantly higher than in adjacent tissues. 26363527 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE TAM can reverse the MDR of colorectal carcinoma in nude mice, which is independent of the expression of ER; however, no change was observed in the expressive level of mdr1 mRNA. 15742416 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease CTD_human This study suggests that low ABCB1 mRNA levels are an early event in CRC development and that the two polymorphisms affect ABCB1 mRNA levels whereas low NFKB1 mRNA levels occur later in carcinogenesis. 23977225 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR). 22460269 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE We previously reported that the Caudal-related homeobox transcription factor CDX2 transcriptionally regulates MDR1 expression in colorectal cancer. 27060927 2016