Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55076
Gene Symbol: TMEM45A
TMEM45A
0.010 AlteredExpression disease BEFREE This study aimed to investigate the key role of TMEM45A in CRC by knockdown of its expression in 5-FU-resistant CRC cells (HCT-8/5-FU and SW480/5-FU) and their parental cells (HCT-8 and SW480). 31788833 2020
Entrez Id: 25790
Gene Symbol: CFAP45
CFAP45
0.010 Biomarker disease BEFREE Taken together, VPS33B as a tumor suppressor is easily dysregulated by chemical carcinogens and it interacts with NESG1 to modulate the EGFR/RAS/ERK/c-Myc/p53/miR-133a-3p feedback loop and thus suppress the malignant phenotype of CRC. 31125123 2020
Entrez Id: 5296
Gene Symbol: PIK3R2
PIK3R2
0.010 Biomarker disease BEFREE DC-SIGN activation recruited Lyn and p85 to form the DC-SIGN-Lyn-p85 complex, which promoted CRC metastasis by increasing PI3K/Akt/β-catenin signaling in tyrosine kinase Lyn-dependent manner. 31217502 2020
Entrez Id: 3301
Gene Symbol: DNAJA1
DNAJA1
0.010 AlteredExpression disease BEFREE High level of DNAJA1 predicted poor prognosis for CRC patients. 31477839 2020
Entrez Id: 25907
Gene Symbol: TMEM158
TMEM158
0.010 Biomarker disease BEFREE Collectively, these results demonstrated that TMEM158 is a significant regulator of tumorigenesis and drug resistance in CRC and provided evidence that TMEM158 may be a promising target for CRC therapy. 31389251 2020
Entrez Id: 5429
Gene Symbol: POLH
POLH
0.010 Biomarker disease BEFREE POLK and POLH are potential prognostic biomarkers in CRC. 31650563 2020
Entrez Id: 9569
Gene Symbol: GTF2IRD1
GTF2IRD1
0.010 Biomarker disease BEFREE We further investigated the oncogenic mechanisms through which GTF2IRD1 promoted CRC progression. 31758608 2020
Entrez Id: 345
Gene Symbol: APOC3
APOC3
0.010 Biomarker disease BEFREE Two peptides from APOC3 and THBS1 are validated by PRM as potential biomarkers for non-invasive diagnosis of colorectal cancer. 31502404 2020
Entrez Id: 3702
Gene Symbol: ITK
ITK
0.010 AlteredExpression disease BEFREE Enhanced PLAGL2 expression was significantly associated with EMT-related proteins in CRC. 31827238 2020
Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1
0.010 Biomarker disease BEFREE When test results for BMP3 and NDRG4 were combined, the DOR of CRC detection was 98.36, which was higher than that for BMP3 and NDRG4 separately. 31097151 2020
Entrez Id: 100126296
Gene Symbol: MIR298
MIR298
0.010 AlteredExpression disease BEFREE Also, the aberrant level of miR-298 contributed with CRC tumor differentiation, TNM stage and lymph node metastasis (p < .001), and independently associated with poor survival of CRC patients (p < .029; hazard ratio: 1.292; 95% confidence interval: 0.339-2.184). 31621072 2020
Entrez Id: 9937
Gene Symbol: DCLRE1A
DCLRE1A
0.010 Biomarker disease BEFREE This study will evaluate the prognostic value of molecular modulation of double-strand break repair (XRCC2 and XRCC5); DNA damage tolerance/translesion synthesis (POLH, POLK, and POLQ), and interstrand crosslink repair (DCLRE1A) in sporadic colorectal cancer (CRC). 31650563 2020
Entrez Id: 10230
Gene Symbol: NBR2
NBR2
0.010 Biomarker disease BEFREE We investigated the role of NBR2 in colorectal cancer. 31571148 2020
Entrez Id: 149837
Gene Symbol: LINC00654
LINC00654
0.010 Biomarker disease BEFREE The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). 31633800 2020
Entrez Id: 22863
Gene Symbol: ATG14
ATG14
0.010 Biomarker disease BEFREE Our research indicated that the novel axis of SNHG14/miR-186/ATG14 could play a vital role in regulating CRC cell progression. 31704614 2020
Entrez Id: 574454
Gene Symbol: MIR496
MIR496
0.010 Biomarker disease BEFREE Our results confirmed that the miR-496/RASSF6 axis is involved in Wnt pathway-mediated tumor metastasis, highlighting its potential as a therapeutic target for CRC. 31273789 2020
Entrez Id: 778
Gene Symbol: CACNA1F
CACNA1F
0.010 Biomarker disease BEFREE Four genes, ABCG2, CACNA1F, CYP19A1, and TF, were identified as hub genes by the protein-protein interaction network, which further validated that these genes were correlated with a poor pathologic stage and overall survival in all stages of CRC. 31724326 2020
Entrez Id: 100616360
Gene Symbol: MIR2467
MIR2467
0.010 Biomarker disease BEFREE In addition, hsa_circ_0053277 accelerated cell proliferation rate by acting as a sponge for miR-2467-3p in CRC. 31549406 2020
Entrez Id: 309
Gene Symbol: ANXA6
ANXA6
0.010 Biomarker disease BEFREE We conclude that Hp, LAMP1, SYNE2, LRG1, RBP4, FN1 and ANXA6 may be of value as stool biomarkers for early detection of high-risk adenomas and CRCs.This article is protected by copyright.All rights reserved. 31784980 2020
Entrez Id: 23186
Gene Symbol: RCOR1
RCOR1
0.010 GeneticVariation disease BEFREE Implications: Our data supports the hypothesis that inhibitors targeting the CoREST complex may be clinically effective in CRC patients harboring PIK3CA mutations. 31704733 2020
Entrez Id: 2634
Gene Symbol: GBP2
GBP2
0.010 AlteredExpression disease BEFREE Forced exogenous expression of GBP-2 in PTX-resistant CRC cell lines resulted in more sensitivity to PTX because of the demonstration of less cell proliferation, invasion, and more apoptosis. 31489998 2020
Entrez Id: 51009
Gene Symbol: DERL2
DERL2
0.010 GeneticVariation disease BEFREE Colorectal cancer (CRC) remains a major cause of carcinoma-related deaths worldwide. 31769193 2020
Entrez Id: 3821
Gene Symbol: KLRC1
KLRC1
0.010 Biomarker disease BEFREE However, the expression of its specific receptor CD94/NKG2 by intraepithelial tumor-infiltrating lymphocytes, their exact phenotype and function, as well as the relation with the molecular status of colorectal cancer and prognosis remain unknown. 31409873 2020
Entrez Id: 54776
Gene Symbol: PPP1R12C
PPP1R12C
0.010 Biomarker disease BEFREE DC-SIGN activation recruited Lyn and p85 to form the DC-SIGN-Lyn-p85 complex, which promoted CRC metastasis by increasing PI3K/Akt/β-catenin signaling in tyrosine kinase Lyn-dependent manner. 31217502 2020
Entrez Id: 100500907
Gene Symbol: MIR3150B
MIR3150B
0.010 Biomarker disease BEFREE MiR-3150b-3p might function as a promising tumor suppressor in CRC. 31678970 2020