Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Immunostaining was performed for Netrin-1 (deleted in colorectal carcinoma [DCC], UNC5A) and GDNF receptors (rearranged during transfection [Ret], glycosylphosphatidylinositol-linked cell surface receptors [GFRα1, GFRα2, GFRα3]). 30811036 2019
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Early-onset CRC is not only distinct from traditional CRC: special consideration should be given to and further investigations should be performed for both very young patients with CRC (18-29 years) and those with predisposing conditions. 30854646 2019
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Our study demonstrated the concurrent misregulation of DCC and LOC100287225 in colorectal cancer. 26429648 2017
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE Combined analysis of data obtained from individuals of either Kazakh or Russian decent showed a significant association with increased CRC risk in the following genotypes: DCC (32008376G/G and G/A versus A/A; OR = 3.45, 95 % confidence interval (95 %CI) = 1.75-6.81, χ (2) = 14.07, p < 0.0002), MLH1 (-93G/G versus G/A and A/A; OR = 1.45, 95 %CI = 1.02-2.07, χ (2) = 4.21, p < 0.04), TP53 (Pro72Pro; OR = 3.80, 95 %CI = 2.46-5.88, χ (2) = 61.27, p < 0.0001), combination GSTT1 deletions with heterozygotes versus normal homozygotes (OR = 1.43, 95 %CI = 1.00-2.04, χ (2) = 3.90, p < 0.05), and GSTM1 deletions (OR = 1.83, 95 %CI = 1.28-2.63, χ (2) = 11.04, p < .001). 25249451 2015
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Well-known genetic bases for the carcinogenesis of CRC include chromosomal changes characteristic of the chromosomal instability pathway which correlates with specific and well-defined genetic alterations (such as APC, K-RAS, DCC and p53) and genomic instability characteristics for the mutator pathway focused on KRAS and BRAF mutations. 26469098 2015
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 AlteredExpression disease BEFREE Influence of the DCC gene on proliferation and carcinoembryonic antigen expression in the human colorectal cancer cell line SW1116. 26345965 2015
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Bisulfite-treated DNA samples from 73 eligible patients were amplified by quantitative methylation-specific polymerase chain reaction (QMSP) targeting 6 genes (deleted in colorectal cancer [DCC], endothelin receptor type B [EDNRB], homeobox protein A9 [HOXA9], kinesin family member 1A [KIF1A], nidogen-2 [NID2], and N-methyl D-aspartate receptor subtype 2B [NR2B]). 25773145 2015
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE Here, we sought novel tumor-suppressor genes that predispose to CRC by exome resequencing 50 sporadic patients with advanced CRC (18 diagnosed ≤35 years of age) at a mean coverage of 30×. 23585368 2013
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 AlteredExpression disease BEFREE DCC gene expression is lost or markedly reduced in the majority of advanced colorectal cancers and, by functioning as a dependence receptor, DCC has been shown to induce apoptosis unless engaged by its ligand, netrin-1 (ref.2). 22158121 2011
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 PosttranslationalModification disease BEFREE Recently, we examined the methylation status of the DCC gene in colorectal carcinomas and found that aberrant methylation of the DCC gene was detected in 28 out of the 50 (56%) primary colon carcinomas. 20150623 2010
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 AlteredExpression disease BEFREE Based on the observation that netrin-1, the anti-apoptotic ligand for the dependence receptors DCC and UNC5H is up-regulated in colonic crypts in response to NF-kappaB, we show here that colorectal cancers from inflammatory bowel diseases patients have selected up-regulation of netrin-1. 19721007 2009
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE The methylation status of the UNC5C and DCC genes were examined in primary carcinomas and the corresponding normal tissues derived from 50 patients with colorectal cancer using quantitative methylation-specific polymerase chain reaction (qMSP). 19242752 2009
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Phenotypic analogy to mice with homozygous inactivation of Ntn1 encoding the secreted axonal guidance protein netrin1, or Dcc encoding its receptor Deleted in Colorectal Cancer led us to perform sequence analysis of NTN1 and DCC in all the patients.No pathogenic mutations were found. 17690130 2007
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE In contrast, distinct MIN-tumor-associated DNA amplifications were detected for E2F5 (8p22-q21.3), GARP (11q13.5-q14), ATM (11q22.3), KAL (Xp22.3), and XIST (Xq13.2) as well as DNA deletions for RAF1 (3p25), DCC (18q21.3), and KEN (21q tel). aCGH revealed distinct DNA copy number changes of oncogenes and tumor suppressor genes in CIN- and MIN-type sporadic colorectal carcinomas. 17143621 2007
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Allelic imbalances at DCC were determined in CRCs. 18054557 2007
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE Although none of these genetic alterations showed a significant prognostic value, specific mutation of K-ras gene and DCC LOH phenotype might have a predictive prognostic implication in colorectal cancer. 17410283 2007
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE Data are insufficient to recommend the routine use of p53, ras, thymidine synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, microsatellite instability, 18q loss of heterozygosity, or deleted in colon cancer (DCC) protein in the management of patients with colorectal cancer. 17060676 2006
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis. 16125380 2005
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease CTD_human Our results indicate that expression of the DCC protein in CRC metastases is similar to that observed in the corresponding primary tumors and represents a dominant predictor of survival in patients with unresectable, advanced CRC who are undergoing palliative FU-based chemotherapy. 15365072 2004
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE We previously used microcell-mediated chromosome transfer (MMCT) into the CRC cell line SW620 to map a approximately 7.7-Mb colorectal cancer-suppressor region (CRCSR) at 8p22-23.1. 15139003 2004
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE No association was observed between the Arg201Gly polymorphism of DCC and colorectal cancer risk. 15646429 2004
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survival. 15333653 2004
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 Biomarker disease BEFREE However, thus far few studies have analyzed the impact of numerical abnormalities of chromosomes 17 and 18, which carry the p53 and DCC plus SHAD4/DPC4 genes involved in colorectal cancer, on the clinical and biological behaviors of the disease. 12500293 2003
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 GeneticVariation disease BEFREE Codon 201 polymorphism of DCC gene is a prognostic factor in patients with colorectal cancer. 12787729 2003
Entrez Id: 1630
Gene Symbol: DCC
DCC
0.700 AlteredExpression disease BEFREE A polymorphic change (Arg to Gly) at DCC codon 201 is related to advanced colorectal carcinoma and increases in the tumors with absent DCC protein expression. 11571626 2001