Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 AlteredExpression disease BEFREE Serum IGFBP-3 levels in CRC were lower than those of controls (4.68 [3.56, 5.77] vs 5.44 [4.77, 6.10] µg/mL, P < 0.05). 31218761 2019
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective. 30334445 2018
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE Higher IGFBP3 predicted increased incidence of colorectal cancer in older men independent of conventional risk factors and total IGF1. 29044573 2018
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE In conclusion, we revealed that miR‑197 modulates IGFBP3 and therefore plays a critical role in regulating CRC migration and invasion. 30106114 2018
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE Six SNPs in the INS, IGF-I, and IGFBP3 genes were associated with CRC risk, and those associations differed between non-obese/active and obese/inactive women and between E nonusers and users. 29023587 2017
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 PosttranslationalModification disease BEFREE IGFBP-3 methylation of DNA from 115 PTs and 1641 LNs in patients with stage II CRC from 2 independent cohorts was analyzed. 25822686 2016
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE However, no statistically significant association was noted between IGFBP-3 A-202C polymorphism and colorectal cancer risk. 25966104 2015
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) genes were associated with CRC risk. 25557790 2015
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE Our data also revealed that IGFBP3 hypermethylation may serve as an independent prognostic and predictive biomarker in stage II and III CRC patients. 25127039 2014
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE This meta-analysis demonstrates that there is no association of IGFBP-3 gene rs2854744 and rs2854746 polymorphisms with CRC risk. 24464126 2014
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE The results suggest that the IGFBP3 A-202C and Gly32Ala polymorphisms are not associated with colorectal cancer susceptibility. 23527244 2013
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE Expression of ADAM28 and IGFBP-3 genes in patients with colorectal cancer - a preliminary report. 23527725 2013
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE The associations of four single nucleotide polymorphisms (SNPs) in IGF-I (rs6214), IGFBP-3 (rs3110697), INSR (rs1052371), and IRS2 (rs2289046) genes with the risk of CRC were evaluated using a case-control design with 167 CRC cases and 277 controls by the PCR-RFLP method. 24175768 2013
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE Our experiments on silencing IGFBP3 or IGFBP7 in the two human CRC cell lines SW480, Caco2, and in the rat CRC cell line CC531 show reduced proliferation, colony formation, and for IGFBP3, also reduced migration. 21525788 2011
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247 2011
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer. 19784788 2010
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE A number of the proteins in these smaller subnetworks have been associated with the progression (CSNK2A2, PLK1, and IGFBP3) or metastatic potential (PDGFRB) of CRC. 19098285 2009
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE Data suggest that the exon 1 G2133C missense variant of IGFBP3 may be a susceptibility factor for colorectal cancer in Chinese subjects. 19492232 2009
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 PosttranslationalModification disease BEFREE IGFBP-3 methylation was detected in 6 of 13 (46%) and 16 of 24 (67%) GC cell lines and tumors, respectively; 4 of 8 (50%) and 15 of 26 (58%) CRC cell lines and tumors, respectively; 3 of 11 (27%) and 7 of 39 (18%) BC cell lines and tumors, respectively and 1 of 5 (20%) and 18 of 56 (32%) MM cell lines and tumors, respectively. 17096329 2007
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 PosttranslationalModification disease BEFREE In conclusion, IGFBP3 methylation is inversely associated with MSI in CIMP-high colorectal cancers, and this relationship is limited to p53-negative tumors. 18084616 2007
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE We did not find any association between the CA repeat length or any of the SNPs in the IGF1 and the IGFBP3 genes and the risk of CRC. 18031946 2007
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE Although we were able to confirm this genotype-phenotype association, the -202A/C IGFBP3 SNP was not significantly associated with colorectal cancer risk. 15668488 2005
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 GeneticVariation disease BEFREE IGFBP-3 genotype was also a significant effect modifier of the relationship between risk factors and colorectal cancer: The positive association between BMI and colorectal cancer was observed only among men (P(interaction) < 0.01) and women (P(interaction) = 0.06) with the GG genotype; the inverse association between postmenopausal hormone use and colorectal cancer was observed only among women with the GG genotype (P = 0.01) and the inverse association between physical activity and colorectal cancer was observed only among men who carried the C allele (P < 0.01). 15894673 2005
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 AlteredExpression disease BEFREE We evaluated the association of polymorphisms in IGF-1 and IGFBP-3 and circulating levels of IGF-1 and IGFBP-3 in 323 population-based control subjects enrolled in a case-control study of colorectal cancer from September 1999 through February 2002. 15941947 2005
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.600 Biomarker disease BEFREE IGF-binding protein-3 (IGFBP-3) has been reported to exert a protective influence on the pathogenesis of colorectal cancer. 16322329 2005