Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE In this review, we will present up to date information on the role of miRNA-31-3p and miR-31-5p in CRC with a particular focus in treatment response of metastatic K-RAS wild-type CRC treated with anti-EGFR molecules. 31786833 2020
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE Elevated miR-31 expression is associated with poor outcome in colorectal cancer (CRC). 30447009 2019
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE The diagnostic sensitivity, specificity and accordance rates of positive miR-27a and miR-31 expression in colorectal cancer were recorded. 31452786 2019
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE The aim of our study is to establish whether miR-31-5p is an oncogene in human colorectal cancers that are resistant to OXA and further confirm its malignant phenotype-associated target molecule. 31623173 2019
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE MiR-31-5p is highly expressed in colorectal cancer and is critical for the cell proliferation, cell cycle, migration, invasion and apoptosis. 30396078 2019
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE No significant changes in the expression of miR-31-3p were observed when sequential tissue biopsies were tested in long-term or poor responders to anti-EGFR mAbs. miR-31-3p scores were similar when pretreatment biopsies were compared with treatment-naïve archival tissues (often primary colorectal cancer). 30952636 2019
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE Collectively, our findings revealed that ENST00000547547 reduced chemoresistance in 5-FU of 5-FU-resistant CRC cells through competitive binding to miR-31 and has the potential to serve as a therapeutic target in CRC patients. 29115526 2018
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE Correlation analysis was performed among the expression levels of miR‑31, LOC554202, and their association with clinicopathological parameters and/or survival rates. miR‑31 and LOC554202 were expressed at high levels in CRC (P<0.01) compared with adjacent intestinal mucosa. 30015936 2018
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE In addition, as a sponge of miR-31, the low level of hsa_circ_0000523 led to activation of Wnt/β-catenin signaling pathway, inducing the subsequent progress of colorectal cancer. 30403259 2018
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE And the level of circ_0026344 was reversely correlated with both miR-21 and miR-31 levels in CRC tissues. 29928882 2018
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE In addition, dynamic postoperative miR-31, 141 and 16 levels are potential biomarkers for the early detection of recurrence during CRC surveillance. 28809863 2017
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE In this study, we identified the host gene of mouse miR-31 and found that miR-31 was over-expressed in both human colorectal cancer and mouse colon cancer models. 28600172 2017
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE This supports miR-31-3p as a promising predictive biomarker for anti-EGFR therapy in KRAS WT advanced colorectal cancer. 29212194 2017
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE We recently suggested that miR-31 regulates the signaling pathway downstream of epidermal growth factor receptor (EGFR) in colorectal cancer. 28147317 2017
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 PosttranslationalModification disease BEFREE We therefore evaluated EZH2 expression using immunohistochemistry and assessed miR-31 and epigenetic alterations using 301 colorectal carcinomas and 207 premalignant lesions. 26871294 2016
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE In summary, miR-31 can inhibit autophagy in colorectal CAFs, affect colorectal cancer development, and increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. 27793031 2016
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE The up-regulated expression of miR-31 may play an oncogenic role in the early stage of carcinogenesis in colorectal cancers. 26173758 2015
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE We compared the metastasis-site derived (SW620) and primary site derived (SW480) human colorectal cancer (CRC) cell lines, and (as a proof of principle) evaluated the metastasis relevant miR-31 as a first example. 26561203 2015
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE Here, we form four major conclusions regarding the role of these proteins in CRC and their potential clinical value: (i) SATB2 is a sensitive marker to distinguish CRC from other cancer types, (ii) Reduced expression of SATB2 in CRC is associated with poor prognosis, (iii) High levels of SATB1 expression facilitate CRC and are associated with poor prognosis and (iv) Overexpression of miR-31 and -182 in CRC leads to more aggressive cancer. 25543122 2015
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE Therefore, we hypothesized that miR-31-5p can be a useful biomarker for anti-EGFR therapy in CRC. 25472647 2015
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. 25232271 2014
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE Additionally, correlation of the miR-31 expression with clinicopathologic features in CRC samples was examined in support of the driving role of newly identified miR-31/FIH-1 nexus in CRC tumorigenesis. 24521875 2014
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 GeneticVariation disease BEFREE Moreover, proliferation and invasion assays were conducted using cell lines. miRNA array analysis revealed that microRNA-31 (miR-31)-5p was the most up-regulated miRNA in CRCs with mutated BRAF (V600E) compared with CRCs possessing wild-type BRAF (including cases with KRAS mutation). 24242331 2014
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 AlteredExpression disease BEFREE For example, in breast cancer loss of miR-31 expression is associated with high risk of metastases, whereas in colorectal cancer high miR-31 expression correlates with advanced disease stage. 23999990 2013
Entrez Id: 407035
Gene Symbol: MIR31
MIR31
0.100 Biomarker disease BEFREE Taken together, our results demonstrate for the first time that miR-31 plays a significant role in activating the RAS signaling pathway through the inhibition of RASA1 translation, thereby improving colorectal cancer cell growth and stimulating tumorigenesis. 23322774 2013