Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer. 31797003 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Combining clinical factors and COX-2/C-MET/KRAS expression status, our models provided accurate prognostic information in CRC. 30720004 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Expression of MIR675-5p or its precursor RNA, H19, correlated with expression of cyclooxygenase-1 and cyclooxygenase-2 and shorter survival times of patients with CRC. 31734182 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population. 29552755 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE <b>Conclusions:</b> In conclusion, the overexpression of both c-Myb and COX-2 would be of prognostic screening value in patients with CRC. 31205515 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Then a GO-based reverse transcription (RT)-LAMP strategy was further developed and applied to detect COX2 mRNA in CRC cancer cells and serum samples with high specificity. 31725282 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Therefore, COX-2, PGE<sub>2</sub> receptors or Akt represent potential targets in the treatment of CRC, particularly in patients exposed to Cd. 31120230 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE We examined CA IX and COX-2 expression in CRC tissues by immunohistochemical staining of 111 samples. 30638861 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway. 29339153 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE This study mainly investigated the novel marker IQGAP3 at serum and tumor tissue levels compared with the markers B7-H4 and cyclooxygenase-2 (COX-2) in patients with colorectal cancer (CRC) and in healthy individuals, aiming to evaluate the diagnostic and prognostic value of IQGAP3 for CRC. 31223291 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Therefore, the present study was designed to assess the prophylactic potentials of probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in conjunction with celecoxib, a selective cox-2 inhibitor in 1,2 dimethylhydrazine dihydrochloride (DMH)-induced experimental colon carcinogenesis, a well-established, well appreciated and widely used model for colorectal cancer that shares many similarities to human sporadic colorectal cancer with respect to response to some promotional and preventive agents. 30183370 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Among them, cyclooxygenase-2 is a prostaglandin-producing hemoprotein, induced during inflammation and in different types of tumor, particularly in colorectal cancer. 30941311 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE The CRC protective effects of apiaceous vegetables are mainly due to the inhibitory effect of FaOH and FaDOH on NF-κB and its downstream inflammatory markers, especially COX-2. 31540047 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. 30826660 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Cyclooxygenase-2 (COX-2) is frequently overexpressed and enhances colorectal cancer (CRC) tumorigenesis, including cancer stem cell (CSC) regulation. 30480806 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE COX-2 expression was positive in 40/49 CRCs, bearing cytoplasmic and heterogeneous staining, from moderate to high intensity. 31614548 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Here, epithelial-mesenchymal transition (EMT) phenotype-based subsets of CTCs and the COX-2 expression status in CTCs were identified and their potential clinical values were assessed in 91 CRC patients. 30260024 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Inflammation and overexpression of cyclooxygenase-2 (COX-2) have been described to play a key role in the progression from nonpathologic intestinal mucosa to colorectal cancer (CRC). 31313358 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE The CRC condition was produced in response to COX-2 and IL-6 induced activation of JAK2/STAT3 which, in turn, was due to the enhanced phosphorylation of JAK2 and STAT3. 29580751 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE COX-2 and proliferating cell nuclear antigen (PCNA) expression were assessed immunohistochemically. lncRNA-CCHE1 expression was upregulated in CRC tissues compared to adjacent non-cancerous tissues, and was significantly associated with larger tumor size, less differentiated histology, advanced dukes' stage, positive lymph node involvement and vascular invasion. 30484108 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic profile. 30700940 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE In the COS-treated CRC group (CMCOS), COS protected mice from CRC by decreasing the disease activity index, tumor incidences and multiplicity, and the mRNA levels of COX-2, IL-6, TNF-α, IL-1β, IL-10, and IKK-β mRNA in colonic epithelial cells. 31620100 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Increased synthesis of PGE<sub>2</sub> in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE<sub>2</sub>-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH, HPGD), in colonic tumors contributes to increased prostaglandin levels and poor patient survival. 30931980 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE <b>Background:</b> The Adenoma Prevention with Celecoxib (APC) Trial showed that cyclooxygenase-2 (Cox-2) inhibitor, celecoxib, decreased adenoma development in patients at high risk for colorectal cancer. 29769213 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE This review has been written to rediscover the multifaceted potential of PTGS2 targeting, hoping it could act as a starting point for a new and more aware application of NSAIDs against CRC. 29421522 2018