Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group LHGDN DPD and TS expressions were measured by reverse transcription-PCR in surgically resected materials of primary colorectal tumors from 37 patients who went on to receive oral treatment of uracil and tegafur and leucovorin for either synchronous or metachronous metastatic diseases. 12576451 2003
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group LHGDN Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. 14562021 2003
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group LHGDN Comparative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in gastric and colorectal cancers. 15069545 2004
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group CTD_human DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. 17611699 2007
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group BEFREE In this study, the mRNA expression levels of these 81 selected genes and the genes of 5-FU-related enzymes, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyltransferase (OPRT), were measured using real-time quantitative RT-PCR assays of surgically resected materials from primary colorectal tumors in 22 patients. 16477629 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group BEFREE In this study, we analyzed by real-time reverse transcription-PCR (RT-PCR) the expression of DPD and of members of the cellular oscillation machinery, period 1 (Per1), period 2 (Per2), and CLOCK, in primary colorectal tumors and normal colon mucosa derived from the same patients. 17699798 2007
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group BEFREE Median gene expression levels of TP and TS did not differ significantly between primary colorectal tumor and corresponding lymph node metastasis but median DPD gene expression levels in the lymph node metastases were significantly higher compared to matched primary colorectal tumors (p=0.015). 16391809 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group RGD Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats. 23197286 2013
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 GeneticVariation group LHGDN Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer. 17203168 2007
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group LHGDN Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. 17612628 2007
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group BEFREE The observed overexpression of several 5-FU activating genes and DPYD downregulation deduce that chemotherapy naïve colorectal tumors share favorable gene expression profile for 5-FU therapy. 27733154 2016
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group LHGDN The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer. 16786143 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group BEFREE The tumor:normal ratio for DPD mRNA, protein, and activity was relatively stable in liver (0.25, 0.55, and 0.51, respectively) but varied considerably in colon (0.085, 0.9, and 1.25, respectively), consistent with enhanced translation of DPD transcript in primary colorectal tumor. 10499634 1999
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group BEFREE There was no correlation among DPD, TS, and TP expression values in this set of colorectal tumors, which indicated that these gene expressions are independent variables. 10778957 2000
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group LHGDN Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. 14519634 2003
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients. 17047489 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. 19020767 2008
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group CTD_human Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. 15814641 2005
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group BEFREE We did not find any significant differences in TS, TP and DPD gene expression between colorectal tumor and surrounding mucosa. 15875081 2005
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 AlteredExpression group LHGDN We present a novel, standardized approach for TP, DPD, and TS mRNA quantification in archival tissue specimens and applied this to a large series of primary colorectal tumors. 16132996 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.600 Biomarker group CTD_human [Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method]. 15222106 2004