Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group BEFREE MSH2 is one of the genes involved in DNA mismatch repair to maintain fidelity of genomic replication, and defects of MSH2 are directly involved in MSI in hereditary nonpolyposis colorectal tumors and other human tumors. 10397740 1999
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group BEFREE mutS homolog 2 (MSH2) deficiency may be involved in the development of microsatellite instability found in certain sporadic colorectal tumors. 29715107 2018
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer. 17333219 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN A636P is associated with early-onset colon cancer in Ashkenazi Jews. 12595050 2003
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE Although not statistically significant, these results support further research into (i) whether supplemental vitamin D<sub>3</sub> , alone or in combination with calcium, may increase DNA mismatch repair relative to proliferation, increase TGFβ<sub>1</sub> expression, and decrease autocrine/paracrine growth promotion relative to growth inhibition in the colorectal epithelium, all hypothesized to reduce risk for colorectal carcinogenesis; and (ii) the expression of MSH2 relative to mib-1, TGFβ<sub>1</sub> alone, and TGFα relative to TGFβ<sub>1</sub> in the normal-appearing rectal mucosa as potential modifiable, pre-neoplastic markers of risk for colorectal neoplasms. 30499618 2019
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group BEFREE Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2. 20305446 2010
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia. 15996210 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer. 15816455 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. 17569143 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN High proportion of large genomic rearrangements in hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families of the Basque Country. 17582678 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Immunohistochemistry detects mismatch repair gene defects in colorectal cancer. 16684085 2006
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE In contrast, approximately 15-20% of colorectal neoplasms arise through a distinct genetic pathway characterized by microsatellite instability (MSI) associated with frequent loss of expression of one of the DNA mismatch repair enzymes, most often hMLH1 or hMSH2. 9850081 1998
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum. 16786121 2006
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Microsatellite instability (MSI) occurs from the mutational inactivation of the DNA mismatch repair genes, i.e. hMSH2 and hMLH1 in HNPCC, as well as from epigenetic inactivation of hMLH1 in sporadic colorectal tumors. 12808326 2003
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system. 18781619 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE MSI and general loss of MSH2 protein expression could be seen in the colorectal tumor but not in the adrenocortical adenocarcinoma. 11150379 2000
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene. 11782355 2002
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group BEFREE Neoplastic cells within benign and malignant mismatch repair-proficient tumors expressed the protein, but no hMSH2 immunoreactivity was observed in the colorectal tumors of patients with germline hMSH2 mutation. 8542572 1996
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer. 16902769 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. 12792735 2004
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group CTD_human Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE Overall, the prevalence of MSI-H colorectal tumor was 2-3-fold higher, while the defect in the percentage expression of mismatch repair (MMR) genes (hMLH1 and hMSH2) was similar in AA patients compared to the U.S. Caucasian population. 15856472 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers. 18581137 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. 16874859 2006