Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group LHGDN Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy. 18597678 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients. 19082493 2009
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan. 17273745 2007
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group LHGDN Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers. 18855534 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group RGD Correlation between histological differentiation and DNA-synthesizing enzymes in rat colorectal tumors induced with 1, 2-dimethylhydrazine. 10523711 1999
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group LHGDN DPD and TS expressions were measured by reverse transcription-PCR in surgically resected materials of primary colorectal tumors from 37 patients who went on to receive oral treatment of uracil and tegafur and leucovorin for either synchronous or metachronous metastatic diseases. 12576451 2003
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN G>C SNP of thymidylate synthase with respect to colorectal cancer. 17716232 2007
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. 25944804 2015
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group LHGDN Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil. 15260847 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group BEFREE In 44/45 microdissected tumors the TS enhancer genotype was identical between paired samples of colorectal tumor and normal tissue. 11445856 2001
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group BEFREE In this study, the mRNA expression levels of these 81 selected genes and the genes of 5-FU-related enzymes, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyltransferase (OPRT), were measured using real-time quantitative RT-PCR assays of surgically resected materials from primary colorectal tumors in 22 patients. 16477629 2006
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE In this study, we investigated the association between both DPD and TS expressions in primary colorectal tumor and the antitumor effect in patients with metastatic colorectal cancer when treated with a fluoropyrimidine-based protocol. 12576451 2003
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. 16141798 2005
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. 18676755 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. 14760062 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy. 16943523 2006
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors. 10821538 1999
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE Median gene expression levels of TP and TS did not differ significantly between primary colorectal tumor and corresponding lymph node metastasis but median DPD gene expression levels in the lymph node metastases were significantly higher compared to matched primary colorectal tumors (p=0.015). 16391809 2006
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group LHGDN Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis. 19020759 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group LHGDN Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer. 18584349 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group BEFREE Mutations were detected at positions 961 and/or 1031 in the 3'-untranslated regions of the TS gene from the metastases; mutations at these sites were also detected in DNA isolated from normal colon mucosa (n=4) and primary colorectal tumors (n=4). 11686531 2001
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer. 17203168 2007
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer. 18607850 2008
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. 15386371 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE Studies thus far involving colorectal tumors obtained from patients have focused predominantly on the predictive value of levels of TS expression and p53 mutations in determining response to 5-FU. 12084458 2002