Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer. 15571262 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group LHGDN Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. 14760062 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human [Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method]. 15222106 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group CTD_human Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. 15386371 2004
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE In this study, we investigated the association between both DPD and TS expressions in primary colorectal tumor and the antitumor effect in patients with metastatic colorectal cancer when treated with a fluoropyrimidine-based protocol. 12576451 2003
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group LHGDN DPD and TS expressions were measured by reverse transcription-PCR in surgically resected materials of primary colorectal tumors from 37 patients who went on to receive oral treatment of uracil and tegafur and leucovorin for either synchronous or metachronous metastatic diseases. 12576451 2003
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group LHGDN Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed. 12576452 2003
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group LHGDN Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. 14519634 2003
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE Studies thus far involving colorectal tumors obtained from patients have focused predominantly on the predictive value of levels of TS expression and p53 mutations in determining response to 5-FU. 12084458 2002
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group BEFREE Mutations were detected at positions 961 and/or 1031 in the 3'-untranslated regions of the TS gene from the metastases; mutations at these sites were also detected in DNA isolated from normal colon mucosa (n=4) and primary colorectal tumors (n=4). 11686531 2001
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 GeneticVariation group BEFREE In 44/45 microdissected tumors the TS enhancer genotype was identical between paired samples of colorectal tumor and normal tissue. 11445856 2001
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 AlteredExpression group BEFREE Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors. 10821538 1999
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group RGD Correlation between histological differentiation and DNA-synthesizing enzymes in rat colorectal tumors induced with 1, 2-dimethylhydrazine. 10523711 1999
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
0.600 Biomarker group BEFREE This trial demonstrated that intratumoral TS/beta-actin messenger RNA (mRNA) ratio can accurately predict which metastatic colorectal tumors will be resistant to a leucovorin-modulated 5-FU infusion and which have a high likelihood of responding to such a regimen. 9726090 1998