Gene: BRAF ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE A previous analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant BRAF and both events proved to cooperate in tumor cell survival. 23359345 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF V600E is a determinant of sensitivity to proteasome inhibitors. 24107445 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE We investigated the clinical and molecular features of the MSH6 variants, such as the family cancer history, pathological findings, immunohistochemistry, methylation status of the MLH1 promoter and BRAF mutation in the colorectal tumor. 24100870 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 23549875 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. 23251002 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE We assessed archived specimens from 732 incident colorectal tumors and characterized them as microsatellite stable (MSS), MSI high or MSI low, CIMP high or CIMP low, CIMP negative, and positive or negative for BRAF and/or KRAS mutations. 23665275 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE Clinical utility of KRAS and BRAF mutations in a cohort of patients with colorectal neoplasms submitted for microsatellite instability testing. 23773459 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. 22535154 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 Biomarker group BEFREE In this study, 40 wild type KRAS and BRAF colorectal tumors were analyzed to elucidate whether PML-RARa bcr1 fusion gene may play a role in colorectal carcinogenesis. 22167334 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. 22281684 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. 22180495 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR The road to resistance: EGFR mutation and cetuximab. 22310681 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 GeneticVariation group BEFREE However, there is a paucity of information about BRAF mutant colorectal tumors. 22228154 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. 22448344 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. 20857202 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF as a target for cancer therapy. 21426297 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. 21163703 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis. 21716161 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. 21343559 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. 21190184 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. 20619739 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. 20413299 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery. 20350999 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? 21129611 2010