Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group CTD_human Dietary folate and APC mutations in sporadic colorectal cancer. 17116713 2006
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group LHGDN Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. 16951153 2006
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group LHGDN APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel. 17119068 2006
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE The authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented colorectal neoplasms. 15959913 2005
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 AlteredExpression group LHGDN Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. 16356174 2005
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group LHGDN APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance. 15943410 2005
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE Most of the mutated Apc genes in colorectal tumors lack beta-catenin-binding regions and fail to inhibit Wnt signaling, leading to overproliferation of tumor cells. 16158975 2005
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group MGD Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. 15502862 2004
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group LHGDN Somatic mutations of APC gene in carcinomas from hereditary non-polyposis colorectal cancer patients. 15040027 2004
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform. 15251969 2004
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 PosttranslationalModification group LHGDN APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. 15326380 2004
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group CTD_human Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. 12907644 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group MGD Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. 14522940 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group LHGDN Role of APC and DNA mismatch repair genes in the development of colorectal cancers. 14672538 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 AlteredExpression group LHGDN Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers. 12647217 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE Since the adenomatous polyposis coli (APC) gene is mutated in about 80% of sporadic colorectal tumors, and familial adenomatous polyposis is the consequence of a germline mutation of the same gene, we examined whether low alkaline sphingomyelinase activity is linked to APC gene mutations. 12774245 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE Mutations of the adenomatous polyposis coli (APC) gene play a critical role in the development of colorectal neoplasms. 12533826 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE Somatic APC mutations in colorectal tumors with an RER phenotype reflect excessive frameshift mutations, especially in simple repetition tracts within the coding sequence. 12494469 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE Somatic APC mutation, frequently associated with colorectal tumors, is implicated in the early stage of tumorigenesis. 12673484 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group LHGDN Adenomatous polyposis coli truncation alters cytoskeletal structure and microtubule stability in early intestinal tumorigenesis. 12504226 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group MGD Intestinal immune responses in wild-type and Apcmin/+ mouse, a model for colon cancer. 12941845 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group LHGDN Genetic analysis of familial colorectal cancer in Israeli Arabs. 12655564 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group BEFREE Familial adenomatous polyposis (FAP) is a dominantly inherited colorectal tumor predisposition that results from germ-line mutations in the APC gene (chromosome 5q21). 11867715 2002
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group LHGDN The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis. 11920497 2002
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 Biomarker group LHGDN Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis. 11956815 2002