Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | group | BEFREE | Risks of colorectal neoplasms and cardiovascular thromboembolic events after the combined use of selective COX-2 inhibitors and aspirin with 5-year follow-up: a meta-analysis. | 30656820 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Levels of COX-2 mRNA are found over-expressed in almost 80% of the colorectal tumors, compared to paired adjacent normal colorectal mucosa, suggesting a role of COX-2 as a potential biomarker for cancer risk, whereas inhibitors of COX-2 could be of value in chemoprevention of colon cancer. | 24383454 | 2014 | ||||
|
0.080 | AlteredExpression | group | BEFREE | COX-2 overexpression is a frequent, but not universal event in colorectal neoplasms. | 21158711 | 2011 | ||||
|
0.080 | AlteredExpression | group | BEFREE | In addition, COX-2 up-regulation represents a pivotal cellular adaptive response to hypoxia with implication for colorectal tumor cell survival and angiogenesis. | 16818642 | 2006 | ||||
|
0.080 | AlteredExpression | group | BEFREE | In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance. | 15075004 | 2004 | ||||
|
0.080 | Biomarker | group | BEFREE | COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. | 12494894 | 2003 | ||||
|
0.080 | AlteredExpression | group | BEFREE | We analyzed and compared expression of the inducible COX-2 isoform in colorectal neoplasms from patients with hereditary nonpolyposis colorectal cancer (HNPCC), familial adenomatous polyposis (FAP), and sporadic CRC. | 10419916 | 1999 | ||||
|
0.080 | AlteredExpression | group | BEFREE | These data suggest that the LDLr is abnormally regulated in some colorectal tumors and may play a role in the up-regulation of cox-2. | 10471521 | 1999 |