Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE Although not statistically significant, these results support further research into (i) whether supplemental vitamin D<sub>3</sub> , alone or in combination with calcium, may increase DNA mismatch repair relative to proliferation, increase TGFβ<sub>1</sub> expression, and decrease autocrine/paracrine growth promotion relative to growth inhibition in the colorectal epithelium, all hypothesized to reduce risk for colorectal carcinogenesis; and (ii) the expression of MSH2 relative to mib-1, TGFβ<sub>1</sub> alone, and TGFα relative to TGFβ<sub>1</sub> in the normal-appearing rectal mucosa as potential modifiable, pre-neoplastic markers of risk for colorectal neoplasms. 30499618 2019
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group BEFREE mutS homolog 2 (MSH2) deficiency may be involved in the development of microsatellite instability found in certain sporadic colorectal tumors. 29715107 2018
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE This indicates that hemi- and homozygous hypermethylation of the MSH2 promoter and hence complete silencing of MSH2 expression was responsible for the mismatch repair deficiency in both colorectal tumors. 23801599 2013
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group BEFREE Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2. 20305446 2010
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Three new nonsense mutations of MLH1 and MSH2 genes in Korean families with hereditary nonpolyposis colorectal cancer. 19100506 2009
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers. 18581137 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. 18299982 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group CTD_human Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system. 18781619 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393 2008
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. 17569143 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer. 16902769 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN High proportion of large genomic rearrangements in hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families of the Basque Country. 17582678 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer. 17333219 2007
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. 16874859 2006
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum. 16786121 2006
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Immunohistochemistry detects mismatch repair gene defects in colorectal cancer. 16684085 2006
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia. 15996210 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group BEFREE Overall, the prevalence of MSI-H colorectal tumor was 2-3-fold higher, while the defect in the percentage expression of mismatch repair (MMR) genes (hMLH1 and hMSH2) was similar in AA patients compared to the U.S. Caucasian population. 15856472 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. 16106253 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 AlteredExpression group LHGDN Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer. 15816455 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 Biomarker group LHGDN The 5' region of the MSH2 gene involved in hereditary non-polyposis colorectal cancer contains a high density of recombinogenic sequences. 16086322 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group BEFREE The authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented colorectal neoplasms. 15959913 2005
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group LHGDN Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. 12792735 2004
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.400 GeneticVariation group BEFREE We demonstrate in one family that a hMLH3 mutation segregated with disease together with a missense mutation in hMSH2, which makes us hypothesize that these mutations work together in an additive manner and result in an elevated risk of colorectal tumors in the family. 12702580 2003