Gene: TCF7L2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group GWASCAT Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. 30529582 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group GWASCAT GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. 29471430 2018
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516 2016
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group BEFREE The intestine-specific transcription factor CDX2 and Wnt effector TCF7L2 bound near rs16969681, with significantly higher affinity for the risk allele, and CDX2 overexpression in CDX2/GREM1-negative cells caused re-expression of GREM1. rs16969681 influences CRC risk through effects on Wnt-driven GREM1 expression in colorectal tumors. 25131200 2014
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group GWASCAT Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 Biomarker group CTD_human Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 Biomarker group CTD_human Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. 21892161 2011
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group LHGDN Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk. 18478343 2008
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 AlteredExpression group LHGDN A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. 18621708 2008
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 AlteredExpression group LHGDN Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex. 17983804 2007
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 AlteredExpression group BEFREE Accordingly, ICAT down-regulation was correlated with progastrin overexpression and Tcf-4 target gene activation in human colorectal tumors, and ICAT repression was detected in the colon epithelium of tumor-prone, progastrin-overexpressing mice. 17920061 2007
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group LHGDN TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription. 16547505 2006
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 Biomarker group LHGDN Colorectal cancer and genetic alterations in the Wnt pathway. 17143297 2006
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 GeneticVariation group LHGDN Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability. 11980438 2002
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		0.490 AlteredExpression group BEFREE TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors. 12036905 2002