Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. 30099074 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Therapeutic group RGD Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. 29546074 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE However, p53 immunoreactivity was correlated with shorter PFS in patients with colorectal tumors (HR = 2.1, p = 0.03) in a univariate analysis as well as to poorer PFS (HR = 2.6, p = 0.03) and OS (HR = 3.4, p = 0.02) in patients with colorectal tumors with distant metastases, a correlation which remained significant in the multivariate analyses. 29112960 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE In this study, we investigated the clinicopathologic significance of TUFM and p53 expression for the normal-adenoma-carcinoma sequence in colorectal epithelia and evaluated the roles of TUFM during the progression of colorectal tumors. 28449687 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE TP53 was the most commonly mutated gene, with prevalence similar to that of sporadic colorectal tumors (63% of cases). 26764183 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Human colorectal tumors with wild-type TP53 and high PBF expression also had low p53 protein levels (P < 0.05), further emphasizing a putative interaction between these genes in vivo. 25408419 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Multiplex Ligation-dependent Probe Amplification, TP53 sequencing, real-time polymerase chain reaction (PCR) for MUC1 and SCGB2A2 and immunocytochemistry, together with senescence detection assay and real-time microscopic observations were used to analyze primary neoplastic cells isolated from prostate, breast and colorectal tumors, as well as stable cancer cell lines (MCF7, MDA-MB-468, SW962, SK-MEL28, NCI-H1975 and NCI-H469). 25964555 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Heme iron intake was associated with an increased risk of colorectal tumors harboring G>A transitions in KRAS and APC and overexpression of P53. 23983135 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group CTD_human A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. 21946351 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group LHGDN Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. 18419600 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. 18097574 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways. 18176677 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group CTD_human The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer. 17949449 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group LHGDN Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept. 18080767 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group LHGDN Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. 19016757 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN We have analyzed the prevalence of MDM2 gene amplifications and SNP309 in 284 colorectal tumors using a relatively new highly sensitive PCR/ligase detection reaction method in relation to TP53 mutational status and genomic instability. 18314481 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group LHGDN Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. 18619950 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group LHGDN Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. 18794809 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN GSTM, GSTT and p53 polymorphisms as modifiers of clinical outcome in colorectal cancer. 18630481 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group CTD_human K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. 18676755 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression. 18988302 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. 17704924 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE We have analyzed the prevalence of MDM2 gene amplifications and SNP309 in 284 colorectal tumors using a relatively new highly sensitive PCR/ligase detection reaction method in relation to TP53 mutational status and genomic instability. 18314481 2008