TNFSF13B
|
0.090 |
Biomarker
|
disease |
BEFREE |
Antiapoptotic Bcl-2 was linked with exclusion of apoptosis from B cell follicles in CVID ILD and increased survival of naive CVID B cells cultured with BAFF.
|
30843876 |
2019 |
TNFSF13B
|
0.090 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate whether autoantibodies against BAFF (important B cell survival signal), APRIL (important plasma cell survival signal), or Interleukin-21 (important cytokine for immunoglobulin class switch) present an alternative mechanism for the development of the following primary antibody deficiencies (PADs): common variable immune deficiency (CVID) or selective IgA deficiency (sIgAD).
|
28651547 |
2017 |
TNFSF13B
|
0.090 |
Biomarker
|
disease |
BEFREE |
This review delineates the contribution of interleukin (IL)-1, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12, IL-21, interferons, tumor necrosis factor (TNF)-α, IL-17, APRIL (a proliferation inducing ligand) and BAFF (B cell activating factor) in CVID disease and outline their potential therapeutic implications in these patients.
|
24827633 |
2014 |
TNFSF13B
|
0.090 |
Biomarker
|
disease |
BEFREE |
BAFF-R levels inversely correlated with serum BAFF concentration both in CVID and healthy subjects.
|
24809296 |
2014 |
TNFSF13B
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Analyzing BAFF-R expression and BAFF-binding to B cells in common variable immunodeficiency (CVID) patients, we identified two siblings carrying a homozygous deletion in the BAFF-R gene.
|
19666484 |
2009 |
TNFSF13B
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The BAFF and APRIL plasma levels of patients with CVID, IgAD and XLA were significantly higher than those of healthy children.
|
18204790 |
2008 |
TNFSF13B
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Peripheral blood mononuclear cells of CVID subjects had increased levels of BAFF mRNA.
|
17556024 |
2007 |
TNFSF13B
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In fact, mutations in TACI, one of the three BLyS receptors, are associated with CVID.
|
16838132 |
2006 |
TNFSF13B
|
0.090 |
Biomarker
|
disease |
BEFREE |
B lymphocytes from individuals with common variable immunodeficiency respond to B lymphocyte stimulator (BLyS protein) in vitro.
|
14597212 |
2003 |