To date, 5 of the identified loci, at ANAPC1, ADAMTS8, ADAMTS17, ABCA6, and COL6A1, have not previously been reported as associated with corneal disease.
Most notably, an intergenic variant close to ANAPC1 (rs78658973[A], frequency = 28.3%) strongly associates with decreased cell density and accounts for 24% of the population variance in cell density (β = -0.77 SD, P = 1.8 × 10<sup>-314</sup>) and associates with increased CH (β = 0.19 SD, P = 2.6 × 10<sup>-19</sup>) without affecting risk of corneal diseases and glaucoma.