Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE The stromelysin-1 genotype was determined for 496 men with coronary artery disease and cholesterol levels between 4.0 and 8.0 mmol/L, participating in the Regression Growth Evaluation Statin Study (REGRESS) study, a clinical trial assessing the effect of the lipid-lowering drug pravastatin on the progression of atherosclerosis. 10190398 1999
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE Association of MMP-1 (rs1799750)-1607 2G/2G and MMP-3 (rs3025058)-1612 6A/6A Genotypes With Coronary Artery Disease Risk Among Iranian Turks. 31356534 2019
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population. 19438845 2009
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE The functional 5A/6A polymorphism of the stromelysin-1 promoter has been implicated as a potential genetic marker for the progression of angiographically determined atherosclerosis in patients with coronary artery disease. 11116068 2000
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 Biomarker disease CTD_human Thus, the common 5A/6A polymorphism of the human stromelysin-1 promoter appears to play an important role in regulating stromelysin-1 gene expression and may be involved in the progression of coronary heart disease. 8662692 1996
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE The matrix metalloproteinase-3 (MMP-3) 5A/6A promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approach. 15665388 2004
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients. 18830194 2008
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 AlteredExpression disease BEFREE Thus, the common 5A/6A polymorphism of the human stromelysin-1 promoter appears to play an important role in regulating stromelysin-1 gene expression and may be involved in the progression of coronary heart disease. 8662692 1996
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE The stromelysin-1 5A/6A promoter polymorphism is a disease marker for the extent of coronary heart disease. 12515907 2002
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE Influence of genetic polymorphism in matrix metalloproteinase-3 on extent of coronary atherosclerosis and risk of coronary artery stenosis. 20082876 2009
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 Biomarker disease BEFREE Of the variety of MMPs, stromelysin-1 and gelatinase B may have key roles in coronary artery atherosclerosis. 12205736 2002
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE We found no association between the 5A/6A polymorphism in the MMP-3 gene and risk of coronary heart disease. 14499230 2003
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE Genetic polymorphisms of MMP-3 5A/6A and ACE I/D along with conventional ischaemic heart disease risk factors increase the risk of the occurrence of STEMI, while having no influence on the pathogenesis of NSTEMI. 29141503 2018
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men. 12485468 2002
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. 12821236 2003
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 GeneticVariation disease BEFREE The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial. 9699891 1998
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 Biomarker disease BEFREE The present study examined whether the -1612 5A/6A polymorphism in the promoter region of the MMP-3 gene influences serum concentrations of MMP-3 and whether serum concentrations of MMP-3 are related to extent of coronary atherosclerosis and risk of MI. 16238676 2005
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.400 AlteredExpression disease BEFREE In conclusion, the MMP-3 5A/6A polymorphism is significantly associated with the occurrence of acute coronary syndrome, MMP-3 activity, and severity of coronary atherosclerosis. 17027562 2006