Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. 12377749 2002
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 Biomarker disease CTD_human Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. 12136229 2002
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. 12136229 2002
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Although potentially beneficial effects of the short HO-1 allele on lipid profile and serum bilirubin were observed, in contrast to Orientals, the HO-1 genotype was not associated with coronary artery disease in Caucasians. 14691581 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 Biomarker disease BEFREE Intragraft heme oxygenase-1 and coronary artery disease after heart transplantation. 15589739 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE The HO-1 gene GT dinucleotide repeat promoter polymorphism and HO-1 +99G/C variant were evaluated in 199 patients with coronary artery disease after coronary stent implantation and control angiography at 6 months after the intervention. 16020495 2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 Biomarker disease BEFREE This demonstration is the first showing that a physiologically inducible vector expressing of HO-1 genes improves the survival of stem cells in myocardial ischemia. 16198853 2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE To test the hypothesis that the capacity to upregulate HO-1 in response to oxidative stress is an intrinsic marker for susceptibility to coronary atherosclerosis, we assessed stimulation-induced change in HO-1 expression in blood cells in 110 patients who underwent coronary angiography, comparing the results with the extent of coronary atherosclerosis and (GT)(n) repeat polymorphism in the HO-1 gene promoter region, which is believed to affect the gene expression level. 17541213 2007
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients. 18443197 2008
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 AlteredExpression disease BEFREE The protein expression of heme oxygenase-1, hypoxia inducible factor-1alpha, and ubiquitin was significantly stronger in patients with coronary heart disease than in controls, and the expression levels increased with the severity of the disease. 19676145 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE A (GT)n dinucleotide repeat and a -413A>T single nucleotide polymorphism have been reported in the promoter region of HMOX1 to both influence the occurrence of coronary artery disease and myocardial infarction. 19389234 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 AlteredExpression disease BEFREE Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study. 18620357 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE A functional GT-repeat polymorphism in the HO-1 gene promoter was inversely correlated to the development of coronary artery disease in diabetics and development of restenosis following angioplasty in patients. 20796278 2010
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 Biomarker disease BEFREE Although a direct association between HO-1, vulnerable plaque development, and clinical outcome is for now missing, the correlations that have been reported for HO-1 and coronary artery disease point to a possible link. 20656217 2010
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE A functional GT-repeat polymorphism in the heme oxygenase-1 (HO-1) gene promoter is inversely correlated with the development of coronary artery disease and restenosis after clinical angioplasty. 20708634 2010
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis. 22123460 2011
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Short (GT) ( n ) repeats in heme oxygenase-1 gene promoter are associated with lower risk of coronary heart disease in subjects with high levels of oxidative stress. 22120665 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Carotid ultrasound and HO-1 polymorphism improve coronary atherosclerosis prediction. 23293173 2013
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Shorter GT repeats in the heme oxygenase-1 gene promoter are associated with a lower severity score in coronary artery disease. 23602216 2013
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE We analyzed the allelic frequencies of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter in 386 patients with coronary artery disease recruited from January 1999 to July 2001 and followed until August 31, 2012. 24762402 2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE HMOX1 gene promoter polymorphism is not associated with coronary artery disease in Koreans. 25187885 2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Association between heme oxygenase 1 gene promoter polymorphisms and susceptibility to coronary artery disease: a HuGE review and meta-analysis. 24670375 2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.400 GeneticVariation disease BEFREE Heme oxygenase-1 gene promoter polymorphisms are associated with coronary heart disease and restenosis after percutaneous coronary intervention: a meta-analysis. 27825138 2016