Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, reduces the risk for coronary artery disease, and increases a chance of longevity. 19273219 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease. 21628510 2011
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE Toll-like receptor 4 rs11536889 is associated with angiographic extent and severity of coronary artery disease in a Chinese population. 28002812 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Adeno-associated Virus 9-mediated Small RNA Interference of TLR4 Alleviates Myocardial Ischemia and Reperfusion Injury by Inhibition of the NF-κB and MAPK Signaling Pathways in Rats. 30854968 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility. 28793055 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE Association of coronary artery disease with toll-like receptor 4 genetic variants: A meta-analysis. 30784241 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE Association of Toll-like receptor 4 polymorphisms with the risk of coronary artery disease in the ethnic Zhuang population of the Guangxi Province of China. 31082501 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE Decreased adiponectin displayed by real-time quantitative RT-PCR was associated with enhanced cytokines of IL-6 and TNF-α or TLR4 expression level in epicardial adipose tissue, suggesting decreased circulating adiponectin may be useful as a more sensitive predictor for coronary atherosclerosis than routine laboratory examinations. 21226932 2011
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Effect of miR-21/TLR4/NF-κB pathway on myocardial apoptosis in rats with myocardial ischemia-reperfusion. 30536340 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. 20524934 2010
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease CTD_human Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. 20524934 2010
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE Promoter Polymorphism of Toll-Like Receptor 4 is Associated with a Decreased Risk of Coronary Artery Disease: A Case-Control Study in the Chinese Han Population. 28092654 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE RFX1 downregulation contributes to TLR4 overexpression in CD14<sup>+</sup> monocytes via epigenetic mechanisms in coronary artery disease. 30857550 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE SNP-SNP Interaction between TLR4 and MyD88 in Susceptibility to Coronary Artery Disease in the Chinese Han Population. 26959040 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE The cardiac function of TLR4-ko or WT/TLR4-ko mice was less affected by LPS and demonstrated reduced suppression by MI compared with WT. 21126202 2011
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery disease. 25542811 2015
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as reflected by the number of coronary artery stenoses. 24146036 2014
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease. 12957699 2003
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE The G allele of the TLR-4 gene, which is associated with a lower inflammation response, was associated with a lower risk of coronary stenosis but not with the occurrence of MI and hence is not a major factor in the development of coronary atherosclerosis. 17101559 2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE There was a significant linear association between the number of high-risk gene variants (IL6-174CC, SFTPD 11CC and TLR4 299AA) and the proportion of patients with coronary artery disease (P < 0.0005). 19140875 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE These single nucleotide polymorphisms explained 27.8% of variation in the CpG-oligonucleotide-induced IFN-α response and were also associated with Toll-like receptor-7/8- and Toll-like receptor-9-dependent IFN-α and IFN-β responses, but were not associated with inflammatory cytokine production in response to Toll-like receptor-4 stimulation or risk of coronary artery disease in 22,233 cases and 64,762 controls (odds ratio 1.00, 95% CI 0.98-1.02) using Mendelian randomization-based analyses. 25882064 2015
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE Two polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) were determined in 655 men with angiographically documented coronary atherosclerosis. 12742999 2003
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE We found that mRNA expression levels of TLR2 but not TLR 4 and 9 are up-regulated in platelets of patients with ACS when compared to patients without coronary atherosclerosis. 31644579 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 GeneticVariation disease BEFREE We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarction in a cohort of patients with angiographically documented coronary artery disease, and performed a meta-analysis using data sets from three independent studies. 15864121 2005