Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 AlteredExpression disease BEFREE These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. 11588264 2001
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE These results shed new light on the role of APOA5 variants in TG metabolism and coronary heart disease risk. 14729863 2004
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. 15177130 2004
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE However, there was no association between APOA5 gene polymorphisms or haplotypes and coronary artery disease as determined by angiography. 15306190 2004
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride metabolism in Chinese. 15542401 2004
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Genetic variation in the apolipoprotein A-V gene (APOA5) has been associated with variation in plasma triglyceride (TG) levels in African American and white females and males older than 40 years and/or at increased risk of coronary artery disease. 15604515 2005
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese. 15877284 2005
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Apolipoprotein A5 gene polymorphism -1131T-->C: association with plasma lipids and type 2 diabetes mellitus with coronary heart disease in Chinese. 16006256 2005
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE A genetic variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. 16046221 2006
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan. 16054149 2006
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE The possible roles of APOA5 variants in determining the risk of myocardial infarction and coronary artery disease development, as well as in the determination of low-density lipoprotein-particle size or plasma concentrations of C-reactive protein and high-density lipoprotein-cholesterol, are also summarized. 16176166 2005
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE We studied the effects of APOA5 polymorphisms on plasma triglyceride levels in Turks, a population with low levels of HDL cholesterol and a high prevalence of coronary artery disease. 16258166 2006
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study. 16682041 2007
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 Biomarker disease BEFREE Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. 16769999 2006
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Our findings show that the presence of the APOA5*2 and APOA5*3 haplotypes in the APOA5 gene is associated with a higher postprandial response that could be involved in the higher risk of coronary heart disease associated with the 56G and -1131C alleles. 17356049 2007
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE However, data for a possible association of APOA5 variants with coronary heart disease are not consistent. 18415697 2008
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease. 19159622 2009
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE The non-synonymous S19W SNP in APOA5 is also an independent determinant of plasma apo A-I level, severity of coronary atherosclerosis and its progression. 19878569 2009
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease. 20452521 2010
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on ω6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease. 20802161 2010
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE APOA5 -1131T/C polymorphism is associated with coronary artery disease in a Chinese population: a meta-analysis. 21143013 2011
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. 21548985 2011
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 AlteredExpression disease BEFREE Moreover, of the 8 sex-biased genes at these loci, 4 have been directly linked to monogenic disorders of lipid metabolism and show an expression profile in females (elevated expression of ABCA1, APOA5 and LDLR; reduced expression of LIPC) that is consistent with the lower female risk of coronary artery disease. 21858147 2011
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE Apolipoprotein A5 polymorphisms and risk of coronary artery disease: a meta-analysis. 21914952 2011
Entrez Id: 116519
Gene Symbol: APOA5
APOA5
0.400 GeneticVariation disease BEFREE However, little is known on the impact of rare APOA5 mutations for the risk of coronary artery disease; therefore, we screened the APOA5 gene in subjects with CAD. 22914599 2012