Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE DNA polymorphisms of apolipoprotein A-I/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease. 3115275 1987
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The results show for the first time an impaired postprandial lipoprotein removal in a case heterozygote with moderately low HDL cholesterol due to an apolipoprotein A-1 mutation not associated with coronary artery disease. 9125314 1996
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The association between lipoprotein(a) levels, apolipoprotein(a) size and the (TTTTA)(n) polymorphism which is located in the 5' non-coding region of the apo(a) gene was studied in 263 patients with severe coronary heart disease and 97 healthy subjects. 11408005 2001
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Carriers of the apolipoprotein A-I(Milano) (apoA-I(M)) mutant present with very low plasma HDL cholesterol and moderate hypertriglyceridemia, apparently not leading to premature coronary heart disease. 11306522 2001
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. 21712729 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Analysis of a new polymorphism in the human apolipoprotein A-I gene: association with serum lipoprotein levels and coronary heart disease. 8934336 1996
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Human data raised the possibility that coronary heart disease is associated with mutations in the apolipoprotein gene cluster APOA1/C3/A4 that result in multideficiency of cluster-encoded apolipoproteins and hypoalphalipoproteinemia. 16497661 2006
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Apolipoprotein A-I gene polymorphisms: frequency in patients with coronary artery disease and healthy controls and association with serum apo A-I and HDL-cholesterol concentration. 2569310 1989
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE A Pst-I RFLP polymorphism adjacent to the 3' end of the apolipoprotein A-I gene is reported to associate with hypoalphalipoproteinaemia with dominant inheritance in families identified through accelerated coronary heart disease. 8096444 1993
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The ApoA-1 Synthesis Stimulation and intravascular Ultrasound for coronary atheroma Regression Evaluation (ASSURE; NCT01067820) study employed serial intravascular ultrasound (IVUS) measures of coronary atheroma in 281 patients treated with apabetalone or placebo for 26 weeks. 30155718 2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Compound heterozygosity for a structural apolipoprotein A-I variant, apo A-I(L141R)Pisa, and an apolipoprotein A-I null allele in patients with absence of HDL cholesterol, corneal opacifications, and coronary heart disease. 8840853 1996
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE ApoA-I related DNA polymorphism in humans with coronary heart disease. 2876946 1986
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Apolipoprotein A1 polymorphisms and risk of coronary artery disease: a meta-analysis. 28721149 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men. 26535656 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop). 15657615 2005
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Effect of apolipoprotein A1 genetic polymorphisms on lipid profiles and the risk of coronary artery disease. 26173491 2015
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Genetic variation in the cholesteryl ester transfer protein and apolipoprotein A-I genes and its relation to coronary heart disease in a Sri Lankan population. 1975178 1990
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Within the apolipoprotein A-I-C-III-A-IV gene cluster, the Ssti polymorphism in the 3' untranslated region of the apolipoprotein C-III gene is the variant site most consistently and strongly associated with raised plasma triglyceride levels and coronary artery disease. 9211063 1997
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels. 21443680 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease. 18398670 2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE A new case of apoA-I deficiency showing codon 8 nonsense mutation of the apoA-I gene without evidence of coronary heart disease. 7583566 1995
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT. 21875686 2012
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Wild-type apoA-I protein was compared to human variants that either are protective (R173C, Milano) or lead to increased risk for ischaemic heart disease (A164S). 29051568 2017
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE We studied the apolipoprotein A-I/C-III gene cluster polymorphism in 97 Saudi Arabians in relation to coronary artery disease. 1900041 1991
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.400 GeneticVariation disease BEFREE Plasma levels of two lipoprotein risk factors, high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apo A-1), have been shown to be negatively associated with the risk of developing coronary artery disease, and several reports have examined familial factors in HDL-C and apo A-1 levels. 1415250 1992