Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Neovascularization stimulated by VEGF occurs in several important clinical contexts, including myocardial ischemia, retinal disease, and tumor growth. 8756616 1996
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE This report summarizes a phase I clinical experience with a gene-therapy strategy that used an E1(-)E3(-) adenovirus (Ad) gene-transfer vector expressing human vascular endothelial growth factor (VEGF) 121 cDNA (Ad(GV)VEGF121.10) to induce therapeutic angiogenesis in the myocardium of individuals with clinically significant coronary artery disease. 10430759 1999
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Recent experiments performed in this same porcine model of myocardial ischemia have shown that direct intramyocardial gene transfer of naked plasmid DNA encoding VEGF (phVEGF(165), the identical plasmid used in our previous animal and human clinical trials) can be safely and successfully achieved through a minimally invasive chest wall incision. 10426872 1999
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE We correlated the VEGF response to hypoxia in the monocytes harvested from patients with coronary artery disease with the presence of collaterals visualized during routine angiography. 10430770 1999
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE We initiated a phase 1 clinical study to determine the safety and bioactivity of direct myocardial gene transfer of vascular endothelial growth factor (VEGF) as sole therapy for patients with symptomatic myocardial ischemia. 9860779 1999
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. 10509970 1999
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE In this brief review, the role of a prime angiogenic candidate, namely vascular endothelial growth factor (VEGF) and its homologues, in physiological and pathological angiogenesis will be discussed with particular attention to myocardial ischemia and heart failure. 10865845 2000
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Recently, the efficacy of therapeutic angiogenesis using VEGF (vascular endothelial growth factor) gene transfer has been reported in human patients with critical limb ischemia and myocardial ischemia. 11426585 2000
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression disease BEFREE In the dog heart, an important model for studies of myocardial ischemia and angiogenesis, the expression of VEGF remains to be established. 11195786 2000
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 GeneticVariation disease BEFREE 3 years) with chronic stable angina due to angiographically documented coronary artery disease, all of whom had failed conventional therapy (drugs, PTCA, and/or CABG), were treated with direct myocardial injection of phVEGF(165) via a minithoracotomy. 10961959 2000
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Several clinical trials based on intramyocardial injection of VEGF DNA in patients with otherwise inoperable coronary artery disease and intractable angina pectoris have recently been completed. 14728030 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease: anesthetic management and results. 11133594 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE The central role of vascular endothelial growth factor (VEGF) in angiogenesis in health and disease makes it attractive both as a therapeutic target for anti-angiogenic drugs and as a pro-angiogenic cytokine for the treatment of ischaemic heart disease. 11166270 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE The results of application of vascular endothelial growth factor (VEGF) GT strategies for therapeutic angiogenesis in critical limb and myocardial ischemia in pilot clinical trials was reviewed. 11773594 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Direct intramyocardial administration of VEGF(165)-DNA and VEGF(167)-DNA may result occasionally in an enhancement of collateral vascularization in regions with diffuse peripheral coronary artery disease not surgically amenable. 11717016 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Currently, about 200 patients have been treated with intramyocardial VEGF gene therapy for peripheral occlusive artery disease or for myocardial ischemia. 12582471 2002
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease CTD_human Gene therapy of coronary artery disease with phvegf165--early outcome. 14668888 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Therapeutic disease CTD_human Gene therapy of coronary artery disease with phvegf165--early outcome. 14668888 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Catheter-based intracoronary vascular endothelial growth factor (VEGF) gene transfer is a potential treatment for coronary heart disease. 12742981 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE However, more research including large scaled clinical trials is needed before deciding whether the vascular endothelial growth factor therapy either as a gene or a recombinant slow-release protein formulation therapy can be offered to patients with severe coronary artery disease, which cannot be treated with conventional revascularization. 12762479 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE PET for evaluation of differential myocardial perfusion dynamics after VEGF gene therapy and laser therapy in end-stage coronary artery disease. 15347709 2004
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression disease BEFREE Because hypoxia-inducible factor (HIF)-1alpha is a transcriptional activator of vascular endothelial growth factor (VEGF) and is critical for initiating angiogenic responses to hypoxia, we investigated the expression of HIF-1alpha and VEGF in specimens of human heart tissue to elucidate the molecular responses to myocardial ischemia in diabetic patients during unstable angina. 15331549 2004
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Mobilization of endothelial progenitor cells with cytokines potentiates VEGF-2 gene therapy for myocardial ischemia and enhances bone marrow cell incorporation into ischemic myocardium. 15337699 2004
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Our findings suggest a crucial role of VEGF-A in the development of coronary artery disease. 15754021 2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Therapeutic disease CTD_human VEGF polymorphisms and severity of atherosclerosis. 15937083 2005