Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE High-sensitivity C-reactive protein is an independent marker of abnormal coronary vasoreactivity in patients with non-obstructive coronary artery disease. 28760202 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE In this Review, we describe some of these challenges in interpreting MR analyses, including those from studies using genetic variants to assess causality of multiple traits (such as branched-chain amino acids and risk of diabetes mellitus); studies describing pleiotropic variants (for example, C-reactive protein and its contribution to coronary heart disease); and those investigating variants that disrupt normal function of an exposure (for example, HDL cholesterol or IL-6 and coronary heart disease). 28569269 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE Inflammatory Biomarkers Interleukin-6 and C-Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences From the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial. 29066452 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE The combined effects of serum albumin and C-reactive protein (CRP) on clinical outcomes after percutaneous coronary intervention (PCI) were investigated.Methods and Results:A total of 2,164 all-comer patients with coronary artery disease who underwent their first PCI and had data available for preprocedural serum albumin and hs-CRP levels between 2000 and 2011 were studied. 28428450 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE No study examined CRP's association with actual cardiovascular disease (e.g. coronary artery disease) in BD. 28764912 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE We examined whether the association between tHcy and subsequent risk of acute myocardial infarction (AMI) was modified by systemic concentrations of neopterin and C-reactive protein among patients with coronary heart disease. 29097387 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease. 28942872 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Nocturnal intermittent hypoxia and short sleep duration are independently associated with elevated C-reactive protein levels in patients with coronary artery disease. 28153212 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and the soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1) are associated with increased risk of diabetes and coronary heart disease. 27955950 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Based on CRP levels, 10 participants (71.4%) were at intermediate risk of coronary heart disease (range, 1.0-2.3 μg ml<sup>-1</sup> ), while four participants (28.6%) were at low risk (<1.0 μg ml<sup>-1</sup> ). 27566532 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE C-reactive protein (CRP) is significantly associated with cardiovascular diseases; however, whether CRP plays a causal role in coronary artery disease has yet to be determined. 27487299 2016
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE However, after adjustment for heterogeneity, neither GRS showed a significant effect of CRP level (at p < 0.0016) on any of these outcomes, including coronary artery disease, nor on the other 20 complex outcomes studied. 27327646 2016
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease. 26751459 2016
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Despite a strong effect on CRP levels, rs77832441 was not associated with inflammation-related phenotypes including coronary heart disease. 25187575 2015
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Genetic Association Studies Reporting on Variants in the C-Reactive Protein Gene and Coronary Artery Disease: A Meta-Analysis. 26266345 2015
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Evaluation of Hs-CRP levels and interleukin 18 (-137G/C) promoter polymorphism in risk prediction of coronary artery disease in first degree relatives. 25822970 2015
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease CTD_human Blood and urine levels of heavy metal pollutants in female and male patients with coronary artery disease. 24868163 2014
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE A novel haplotype within C-reactive protein gene influences CRP levels and coronary heart disease risk in Northwest Indians. 24965144 2014
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE C-reactive protein and coronary heart disease: all said--is not it? 24808639 2014
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Renin-angiotensin system genetic polymorphisms: lack of association with CRP levels in patients with coronary artery disease. 23392788 2014
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE Association between C-reactive protein gene +1059 G/C polymorphism and the risk of coronary heart disease: a meta-analysis. 24342328 2013
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials. 22056216 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE C-reactive protein (CRP) is one of the many molecular factors involved in pathogenesis of coronary artery disease which its plasma levels are associated with increased risk of cardiovascular events. 21720757 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 GeneticVariation disease BEFREE We describe a significant proportion of individual TS females having high levels of vWF, factor VIII, fibrinogen and CRP (15-40%) and an increased frequency of the Leiden mutation, with important associations with CIMT and blood pressure, suggesting that a subset of TS may have an unfavourable haemostatic balance, which may contribute to the increased risk of premature ischaemic heart disease and possibly increase the risk of deep venous and portal vein thrombosis. 21848660 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE As an example, we will review a large genomics study (Elliott et al, JAMA 2009; 302:37-48) that concluded that C-reactive protein (CRP) is likely not a cause of coronary heart disease, although it is a marker for it. 22383552 2012