Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Collectively, these data revealed that Catalpol inhibited apoptosis and oxidative stress in glucose-deprived H9c2 cell through promoting cell mitophagy and modulating estrogen receptor, supporting the notion that Catalpol could be a novel drug candidate against myocardial ischemia for the treatment of cardiovascular diseases. 28292026 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Correlation between polymorphisms in the estrogen receptor α gene and coronary heart disease: A meta-analysis. 27706721 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies. 24599688 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Meta-analysis of the association of the rs2234693 and rs9340799 polymorphisms of estrogen receptor alpha gene with coronary heart disease risk in Chinese Han population. 23471591 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE There was significant enrichment of ESR1 binding present in multiple datasets near genomic regions associated with breast cancer (7.45-fold, p = 0.001), height (2.45-fold, p = 0.002), multiple sclerosis (5.97-fold, p < 0.0002) and prostate cancer (4.47-fold, p = 0.0008), and suggestive evidence of ESR1 enrichment for regions associated with coronary artery disease, ovarian cancer, Parkinson's disease, polycystic ovarian syndrome and testicular cancer. 24171864 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population. 22284250 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Post-genomic update on a classical candidate gene for coronary artery disease: ESR1. 21984528 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE To test whether estrogen receptor polymorphisms modify the effects of postmenopausal hormone therapy on biomarkers and on risk of coronary heart disease events, stroke, or venous thromboembolism. 21106950 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease CTD_human Modulation of gene expression by Polyalthia longifolia in postmenopausal women with coronary artery disease: an in vitro study. 20559769 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE ESR1 genetic variants, haplotypes and the risk of coronary heart disease and ischemic stroke in the Finnish population: a prospective follow-up study. 20153472 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Qualitative assessment of previous evidence and an updated meta-analysis confirms lack of association between the ESR1 rs2234693 (PvuII) variant and coronary heart disease in men and women. 19608186 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism. 19008156 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography. 19318036 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE There have been studies examining the association between coronary artery disease and the estrogen receptor alpha (ESR1) gene. 18360040 2008
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population. 18582450 2008
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE The relationship of the ESR1 gene polymorphisms with the presence of coronary artery disease determined by coronary angiography. 18294052 2007
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Effect of hormone replacement therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha IVS1-397 C/C genotype and established coronary artery disease. 16612068 2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population. 16612467 2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE In previous association studies, the -397T/C (rs2234693) and -351A/G (rs9340799) single nucleotide polymorphisms in the estrogen receptor alpha gene (ESR1) have been implicated in the risk of coronary atherosclerosis and myocardial infarction. 16203927 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Estrogen receptor alpha gene polymorphisms are associated with the angiographic extent of coronary artery disease. 16159931 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE The reported association has the potential to explain the risks associated with estrogen use in certain women and a recent report of association between an ESR1 haplotype comprised of c.454-397 T and c.454-351 A alleles with increased myocardial infarction and ischaemic heart disease, independent of the standard, established cardiovascular risk factors. 16014638 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Estrogen receptor alpha (ESR1) gene variation is associated with a range of important estrogen-dependent characteristics, including responses of lipid profile and atherosclerotic severity to hormone replacement therapy, coronary heart disease risk, and migraine. 16179580 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 AlteredExpression disease BEFREE Short-term transdermal estradiol enhances nitric oxide synthase III and estrogen receptor mRNA expression in arteries of women with coronary artery disease. 16207548 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease. 14972425 2004
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Molecular analysis of the estrogen receptor alpha gene in men with coronary artery disease: association with disease status. 12691862 2003