Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 PosttranslationalModification disease BEFREE Variations of the proprotein convertase subtilisin/kexin type 9 gene in coronary artery disease. 30947598 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 AlteredExpression disease BEFREE Few studies have investigated the relationship between PCSK9 levels and the severity of coronary artery disease in patients with acute coronary syndrome; thus, we herein aimed to investigate this relationship in patients with non-ST-elevation myocardial infarction (NSTEMI) who underwent coronary angiography. 31206403 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE These observations suggest that PCSK9 is inter-twined with inflammation with implications in atherosclerosis and its major consequence - myocardial ischemia. 31746997 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 GeneticVariation disease BEFREE Loss-of-function mutations in PCSK-9 gene invariably translates into lower levels of LDL, and decreased risk of developing coronary artery disease. 30953636 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 AlteredExpression disease BEFREE We measured PCSK9 and Lp(a) levels in plasma samples from Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial patients with coronary heart disease and/or type II diabetes (T2D) mellitus. 29103916 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Cost effectiveness of lifelong therapy with PCSK9 inhibitors for lowering cardiovascular events in patients with stable coronary artery disease: Insights from the Ludwigshafen Risk and Cardiovascular Health cohort. 31207358 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE We conducted a comprehensive search of electronic databases, up to December 1, 2018, for all RCTs comparing PCSK9 inhibition to placebo or ezetimibe in patients with hypercholesterolemia or coronary artery disease receiving maximally tolerated statin for primary or secondary prevention of mortality and cardiovascular outcomes. 31679643 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 AlteredExpression disease BEFREE Association between plasma levels of PCSK9 and the presence of coronary artery disease in Japanese. 29974199 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 GeneticVariation disease BEFREE Soon after, studies uncovered the role of PCSK9 in the regulation of LDL-receptor recycling and identified loss-of-function variants of PCSK9 that were associated with low circulating levels of LDL cholesterol (LDL-C) and a reduced risk of coronary artery disease. 30420622 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 AlteredExpression disease BEFREE Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina. 31672148 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 AlteredExpression disease BEFREE Correction to: Association between plasma levels of PCSK9 and the presence of coronary artery disease in Japanese. 30076455 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE The addition of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, evolocumab, to statin therapy produced incremental regression of atherosclerotic plaques and a collaborative prevention of cardiovascular events in patients with coronary artery disease. 31495548 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE PCSK9 inhibitor prescribing increased over time for patients with coronary artery disease or coronary heart disease but not for those with dyslipidemia. 31020929 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Proprotein convertase subtilisin/kexin type 9 (PCSK9) down-regulates the low-density lipoprotein (LDL) receptor, elevating LDL cholesterol and accelerating atherosclerotic heart disease, making it a promising cardiovascular drug target. 29259136 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 AlteredExpression disease BEFREE Relationship between myocardial ischaemia and PCSK9 expression and autophagy was examined in cultured mouse cardiomyocytes. 29800228 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE To investigate the association of each PCSK9 subtype with coronary atherosclerosis in HeFH. 28502498 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Background Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) has been reported to be related to several risk factors and diseases such as inflammatory markers and coronary artery disease. 28166668 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease. 30112872 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE A state transition Markov model was developed to model the cost-effectiveness of PCSK9 inhibitors for prevention of coronary heart disease, ischaemic strokes, and death among high-risk patient subpopulations in Norway, in both primary and secondary settings. 28444187 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Incremental low-density lipoprotein (LDL) cholesterol lowering with the proprotein convertase subtilisin kexin type 9 inhibitor evolocumab regresses coronary atherosclerosis in statin-treated patients. 30336824 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE The aim of this review is to summarize the recent major advances in cardiovascular pharmacotherapy, with a focus on (1) the new approved drug for treatment of heart failure with reduced ejection fraction-sacubitril/valsartan; (2) proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors; (3) the novel reversal agents for non-vitamin K oral anticoagulants (NOACs); and finally, (4) new evidence on pharmacological treatment of coronary artery disease. 29589064 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease. 29885102 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Estimated individual lifetime benefit from PCSK9 inhibition in statin-treated patients with coronary artery disease. 29622600 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE Using MR (Mendelian Randomization), we detected significant causal effects of circulating PCSK9 on coronary artery disease status and severity, carotid plaques, and intima-media thickness. 29748315 2018
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.400 Biomarker disease BEFREE The aim of this study was to characterize the alterations in the lipidome of plasma and lipoprotein particles after administration of PCSK9 inhibiting antibody to patients with established coronary heart disease. 29366988 2018