Gene polymorphisms in superoxide dismutase (<i>SOD2</i> and <i>SOD3</i>), glutathione peroxidase-3 (<i>GPX3</i>), and glutathione S-transferase theta-1 (<i>GSTT1</i>) may enable oxidative stress-related lipid abnormalities and severity of coronary atherosclerosis.
Because elevated RBC count correlate well with risk of coronary heart disease, it might be concluded that GSTM1 and GSTT1 null genotypes have protective role(s) for developing coronary heart disease.
The common variant in the GSTM1 and GSTT1 genes is related to markers of oxidative stress and inflammation in patients with coronary artery disease: a case-only study.
Male gender (p < 0.001), smoking habits (p = 0.003) and GSTT1(null) genotype (p = 0.003) were significantly correlated with the increasing extent of the coronary atherosclerosis.
The aim of this study was to identify the potential association between GSTM1 and GSTT1 deleted polymorphisms with cardiovascular risk factors and coronary atherosclerosis in two independent urban populations.
Patients who smoke having the null genotypes of GSTM1 (OR: 1.63 (1.10 - 2.63)) and GSTT1 (2.66 (1.50 - 4.72)) and both (3.20 (1.37 - 7.45)) were at a higher risk for developing coronary heart disease.
The results of this analysis of preclinical atherosclerosis extend reports from the ARIC study of an interaction between smoking and GSTT1-1 in relation to the risk of incident coronary heart disease and lower extremity arterial disease.