Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease BEFREE In a necropsy study, we used immunohistochemistry to explore where and to what extent CCL2 and related receptors are present in diseased arteries that caused the death of men with coronary artery disease compared with unaffected arteries. 31739217 2020
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 AlteredExpression disease BEFREE Genetically determined higher MCP-1 levels were further associated with coronary artery disease (OR, 1.04; 95% CI, 1.00-1.08; P=0.04) and myocardial infarction (OR, 1.05; 95% CI, 1.01-1.09; P=0.02), but not with atrial fibrillation. 30586705 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 AlteredExpression disease BEFREE Regulatory Factor X1 Downregulation Contributes to Monocyte Chemoattractant Protein-1 Overexpression in CD14+ Monocytes <i>via</i> Epigenetic Mechanisms in Coronary Heart Disease. 31737059 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease BEFREE Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-κB, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial. 31797473 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease BEFREE Recent studies have indicated that monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation and progression of ischaemic heart disease. 31077149 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease BEFREE Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females. 30557342 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease BEFREE Serum concentrations of MCP-1 and IL-6 in combination predict the presence of coronary artery disease and mortality in subjects undergoing coronary angiography. 28534120 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Association of monocyte chemoattractant protein-1 (MCP-1)-2518A>G polymorphism with susceptibility to coronary artery disease: a meta-analysis. 25875728 2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 AlteredExpression disease BEFREE Serum levels of monocyte chemoattractant protein-1 and all-cause and cardiovascular mortality among patients with coronary artery disease. 25786118 2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Association of -2518A>G promoter polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with type 2 diabetes and coronary artery disease. 23930970 2013
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility. 22752804 2012
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor CCR2 and risk of coronary artery disease: a meta-analysis. 21868018 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease BEFREE Epicardial fat was clearly different from substernal fat because there was a far higher expression of haptoglobin, prostaglandin D(2) synthase, nerve growth factor beta, the soluble vascular endothelial growth factor receptor (FLT1), and alpha1 glycoprotein but not of inflammatory adipokines such as monocyte chemoattractant protein-1, interleukin (IL)-8, IL-1beta, tumor necrosis factor alpha, serum amyloid A, plasminogen activator inhibitor-1, or adiponectin despite underlying coronary atherosclerosis. 20116810 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 AlteredExpression disease BEFREE Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease. 20431065 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Monocyte chemoattractant protein-1-2518 G/A polymorphism, plasma levels, and premature stable coronary artery disease. 19247801 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population. 19332042 2009
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease CTD_human This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease RGD Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. 16297799 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Currently, there is conflicting evidence regarding an association between polymorphisms in CCR2/MCP-1 and CCR5/RANTES and coronary artery disease. 15017357 2004
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Lack of association between the -2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation. 15245376 2004
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 AlteredExpression disease BEFREE In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease. 12239249 2002
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 Biomarker disease CTD_human Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients. 11500196 2001
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.520 Biomarker disease RGD Both EA-pretreatment and routine EA of PC 6 and BL 15 can down-regulate blood TC, TG and HDL contents, raise serum HDL level and suppress the increased expression of CD 40 L and MMP-9 proteins of coronary artery tissue in rats with coronary atherosclerotic heart disease, which may contribute to their effect in improving CHD. 23819214 2013
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.520 Biomarker disease BEFREE In addition, soluble CD40L was determined by ELISA as another biomarker of coronary artery disease. 21091218 2011