Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE A total of 84 children and adolescents were assessed for fasting total homocysteine, methylenetetrahydrofolate reductase polymorphism (C677T mutation), folate and vitamin B12 status, and anthropometric and metabolic risk factors for CHD. 10977031 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Association of apolipoprotein E genotype with early onset of coronary heart disease in Greek men. 16327942 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease LHGDN Both epsilon 4 allele and mutation -219G/T in the promoter are associated with early onset coronary heart disease in Finland. 11862316 2002
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls. 15612980 2005
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E alleles are important genetic markers for dyslipidemia and CHD. 7966894 1994
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index. 26188224 2016
Entrez Id: 7941
Gene Symbol: PLA2G7
PLA2G7
0.500 GeneticVariation disease BEFREE Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. 15115767 2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE MTHFR rs1801131 were identified as loci in Chinese population that were involved in CHD. 26035828 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E (apo E) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. 10094101 1999
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease. 24900971 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease LHGDN Homozygosity for the C677T mutation in the MTHFR gene does not constitute a genetic risk factor for coronary diseases and neural tube defects in the Indonesian Javanese population. 12594357 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)). 22042884 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Among the 57 mothers of CHD-affected children with DS who carried the MTHFR 677CT or TT genotypes and did not have periconceptional folic acid intake, we observed a 2.26-fold increased odds (95% CI 1.25-4.09) of having any CHD-affected child with DS. 19725133 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity. 18403793 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E polymorphism and coronary artery disease. 6882285 1983
Entrez Id: 7941
Gene Symbol: PLA2G7
PLA2G7
0.500 GeneticVariation disease BEFREE Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis. 21107710 2011
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. 20605575 2010
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Genetic variants of apolipoprotein B: relation to serum lipid levels and coronary artery disease among the Finns. 1418918 1992
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease. 16704755 2006
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE In a group of 110 subjects with severe coronary artery disease, two were heterozygous for the apolipoprotein (apo) B arginine3,500----glutamine mutation that characterizes familial defective apo B-100. 1671822 1991
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE The exceptionally low frequency of MTHFR mutant homozygotes in this population suggests that this polymorphism should not be regarded as an important CHD risk factor among Black South Africans. 10428303 1999
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE This disease, which is due to mutation in the low density lipoprotein (LDL) receptor gene and results in deficiency of the LDL receptor, is associated with hypercholesterolemia and premature development of coronary heart disease. 12119548 2003
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE MTHFR C677T is a potential risk factor for CHD in our local residents of Shandong province in China. 26990189 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease LHGDN approximately linear relationship of apoE genotype with LDL-C levels & coronary heart disease risk; compared with individuals with epsilon3/epsilon3 genotype, epsilon2 carriers have lower risk & epsilon4 carriers have a slightly higher risk [review] 17878422 2007