Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Matrix metalloproteinase-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease. 21559835 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE MMP9 rs3918242 TT genotype is associated with elevated serum TG and LDL-C, and enhanced LDL-C-lowering response upon simvastatin treatment in Chinese patients with CHD. 28390432 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association between -1562C>T polymorphism in the promoter region of matrix metalloproteinase-9 and coronary artery disease: a meta-analysis. 24506511 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association between matrix metalloproteinase 9 C-1562T polymorphism and the risk of coronary artery disease: an update systematic review and meta-analysis. 29507703 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis. 24599689 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association of genetic polymorphisms in matrix metalloproteinase-9 and coronary artery disease in the Chinese Han population: a case-control study. 23819814 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients. 22664146 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Circulating concentrations of matrix metalloproteinase 9 (MMP-9) are associated with cardiovascular disease mortality in patients with coronary artery disease. 20184534 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Circulating levels of MMP2 and MMP9 are independently associated with development of an acute MI rather than stable angina as the initial clinical presentation of coronary artery disease. 18035073 2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease LHGDN Circulating levels of MMP2 and MMP9 are independently associated with development of an acute MI rather than stable angina as the initial clinical presentation of coronary artery disease. 18035073 2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE For MMP9 R279Q (rs17576), modest pharmacogenetic findings were observed for combined CHD and the composite CVD outcome. 21887284 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population. 19283512 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Furthermore, omega-6 fatty acids significantly downregulated MMP-2 and MMP-9 expression in our coronary heart disease-induced rat model. 30443948 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Genetic variation, gene-expression and circulating levels of matrix metalloproteinase-9 in patients with stable coronary artery disease. 21963461 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Haplotypic analysis of the MMP-9 gene in relation to coronary artery disease. 12728308 2003
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE In conclusion, we suggest that the TT and CT genotypes and T allele of MMP-9 rs3918242 polymorphism is correlated with an increased risk of coronary artery disease in a Chinese population. 27323016 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE In stable CHD patients with elevated Lp(a), MMP-9 levels are positively associated with the size of the necrotic core of coronary atherosclerotic plaques. 30934954 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE In the total sample, the gelatinase B promoter polymorphism was not associated with the risk of CAD and MI or with the extent of CAD defined either by the number of diseased coronary arteries or--in patients with coronary angiography--by a score for coronary heart disease (CHD) according to the Gensini score. 16179285 2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population. 19435423 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease LHGDN Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. 17364896 2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Plasma MMP-9 concentration was identified as a novel predictor of CV mortality in patients with coronary artery disease. 12668489 2003
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Plasma concentration, genetic variation, and gene expression levels of matrix metalloproteinase 9 in Iranian patients with coronary artery disease. 28400830 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Therapeutic disease RGD Rat coronary atherosclerosis heart disease model can be successfully established by feeding with high-fat diet and intraperitoneal injection of VD3, the permeability of coronary artery in coronary heart disease rat model is significantly increased, which may be related to up-regulation of MMP-9, CD40L, TNF-α and CRP expression. 26261622 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Relationship between serum cytokines receptors and matrix metalloproteinase 9 levels and coronary artery disease. 27910999 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE Role of serum MMP-9 levels and vitamin D receptor polymorphisms in the susceptibility to coronary artery disease: An association study in Iranian population. 28739397 2017