Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Familial hypercholesterolemia (FH) is a genetic disorder with an increased risk of early-onset coronary artery disease. 25962062 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE In addition to the established association between high lipoprotein(a) [Lp(a)] concentrations and coronary artery disease, an association between Lp(a) and venous thromboembolism (VTE) has also been described. 26900838 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE We used linear regression models to assess associations of APOE e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n = 366), and restricted cubic splines to explore dose-response relationships between serum cholesterol levels and cognition depending on APOE polymorphism. 26495840 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Combined, these genetic results anticipate that, beyond low-density lipoprotein, pharmacological lowering of triglyceride-rich lipoproteins or lipoprotein(a) will reduce risk for CHD, but this remains to be proven through randomized controlled trials. 26892959 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Lipoprotein(a) [Lp(a)] has recently been recognized as an independent risk factor for coronary heart disease. 25604958 2016
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Gene variants leading to higher levels of plasma apolipoprotein B-containing lipoproteins [low-density lipoprotein, triglyceride-rich lipoproteins, or lipoprotein(a)] consistently increase risk for CHD. 26892959 2016
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE We confirmed previously observed significant associations between coronary artery disease and low-frequency missense variants in the genes LPA and PCSK9. 26934567 2016
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Premature coronary heart disease and autosomal dominant hypercholesterolemia: Increased risk in women with LDLR mutations. 26892126 2016
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease. 24900971 2015
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. 24916650 2015
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 Biomarker disease BEFREE Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. 25070550 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Common variants of apolipoprotein E and cholesteryl ester transport protein genes in male patients with coronary heart disease and variable body mass index. 24402318 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Results from this study indicate that the MTHFR c.1625A>C genetic variant influences the risk of CHD in the studied population. 25494855 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls. 24755673 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE These preliminary findings indicate that these two MTHFR genetic polymorphisms are related with the risk of CHD in Chinese Han population, and might be potentially utilized as molecular markers. 24720776 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE The association of APOE genotype with ND outcomes was assessed in a combined cohort of patients with single-ventricle CHD enrolled in the Single Ventricle Reconstruction and Infant Single Ventricle trials. 25282659 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians. 26095803 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE Elevated plasma concentrations of lipoprotein(a) (Lp[a]) are an emerging risk factor for the development of coronary heart disease (CHD). 25432390 2015
Entrez Id: 7941
Gene Symbol: PLA2G7
PLA2G7
0.500 GeneticVariation disease BEFREE Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease. 24732951 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 GeneticVariation disease BEFREE Our results support the MTHFR -677T allele as a susceptibility factor for CHD in the Asian maternal population and the -1298 C allele as a risk factor in the Caucasian paediatric population. 25472587 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher risk of cognitive decline and coronary heart disease? 25333200 2015
Entrez Id: 7941
Gene Symbol: PLA2G7
PLA2G7
0.500 GeneticVariation disease BEFREE Associations of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms with circulating PAF-AH levels and risk of coronary heart disease or blood stasis syndrome in the Chinese Han population. 25034894 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.500 GeneticVariation disease BEFREE A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease. 25173947 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE The association between the LPA gene polymorphism and coronary artery disease in Chinese Han population. 24790998 2015
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Recent evidence indicates that PCSK9 also modulates the metabolism of triglyceride-rich apolipoprotein B (apoB) lipoproteins, another important coronary heart disease risk factor. 25070550 2015