Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Lipoprotein(a) [Lp(a)] is a macromolecular complex found in human plasma that combines structural elements from the lipoprotein and blood clotting systems and that is associated with premature coronary heart disease and stroke. 2530631 1989
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.500 GeneticVariation disease BEFREE Homozygotes and compound heterozygotes (i.e., those who carry two different FH genes) are very rare (one in 1,000,000) have severe hypercholesterolemia with xanthomas, and develop coronary heart disease early in life. 2563220 1989
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 Biomarker disease BEFREE Variation in the concentrations of both plasma and low density lipoprotein cholesterol, as well as apolipoprotein B, were related neither to age at death from CHD nor to the clinical course of CHD. 2923577 1989
Entrez Id: 345
Gene Symbol: APOC3
APOC3
0.100 Biomarker disease BEFREE The association between the minor RFLP alleles and polymorphic gene variants (probably the apo AI, apo CIII, or both genes) which enhance liability to CHD accounted for almost 20% of total CHD in this population. 2567428 1989
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.100 GeneticVariation disease BEFREE Apolipoprotein A-I gene polymorphisms: frequency in patients with coronary artery disease and healthy controls and association with serum apo A-I and HDL-cholesterol concentration. 2569310 1989
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease (CHD) risk. 2341810 1990
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE A high-resolution method was used to study the allele frequencies of a hypervariable minisatellite region close to the apolipoprotein B gene in 110 patients with severe coronary disease and in 117 normal controls. 2351870 1990
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels. 1967524 1990
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.200 GeneticVariation disease BEFREE Genetic variation in the cholesteryl ester transfer protein and apolipoprotein A-I genes and its relation to coronary heart disease in a Sri Lankan population. 1975178 1990
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.100 GeneticVariation disease BEFREE Genetic variation in the cholesteryl ester transfer protein and apolipoprotein A-I genes and its relation to coronary heart disease in a Sri Lankan population. 1975178 1990
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
0.060 Biomarker disease BEFREE Although no definite evidence is available showing that tissue plasminogen activator antigen is a risk factor for coronary heart disease, the present study suggests a positive ecologic association between this hemostatic factor and coronary heart disease mortality. 2113352 1990
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation disease BEFREE Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease risk. 2036207 1991
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 GeneticVariation disease BEFREE Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K. 1789809 1991
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.500 Biomarker disease BEFREE To elucidate the association of thermolabile MTHFR with the development of coronary artery disease, we determined the thermostability of lymphocyte MTHFR in 212 patients with proven coronary artery disease and in 202 controls without clinical evidence of atherosclerotic vascular disease. 1998339 1991
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Intermediate-density lipoproteins (IDLs) and lipoprotein (a) are highly atherogenic species that each normally account for up to 10% to 15% total LDL cholesterol but may be disproportionately elevated in pathologic states and may therefore contribute disproportionately to coronary disease risk in certain patients. 1994714 1991
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 GeneticVariation disease BEFREE The value of lipoprotein (a) [Lp(a)] in the prediction of coronary artery disease risk very early in life remains to be established in different racial groups. 1829398 1991
Entrez Id: 338
Gene Symbol: APOB
APOB
0.500 Biomarker disease BEFREE In conclusion, (1) the presence of NIDDM in the proband appears to be associated in siblings with more profound lipid and lipoprotein changes (especially low HDL cholesterol and high total triglycerides) than a history of CHD in the proband, (2) a history of CHD in the proband is associated in children with apolipoprotein changes favouring atherosclerosis (low apolipoprotein A1, high apolipoprotein B, low apolipoprotein A1/B ratio). 2064632 1991
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE Prevalence of lipoprotein (a) [Lp(a)] excess in coronary artery disease. 1827234 1991
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 AlteredExpression disease BEFREE Lipoprotein (a) (Lp(a)) is a low density lipoprotein-like particle which contains the plasminogen-like apolipoprotein a. Lp(a) levels are elevated in patients with atherosclerotic coronary artery disease. 1824942 1991
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.500 Biomarker disease BEFREE This could be explained by the observed rise of lipoprotein (a) between age 2 and 13 years, which was much more pronounced in the group with parents who had CHD. 1929512 1991
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.200 GeneticVariation disease BEFREE We conclude that, in Finns, the CETP RFLPs are not useful markers for the risk of coronary heart disease. 1680788 1991
Entrez Id: 80350
Gene Symbol: LPAL2
LPAL2
0.160 Biomarker disease BEFREE Children of parents with CHD differed from controls in total cholesterol and apolipoprotein A II concentrations. 1929512 1991
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.100 Biomarker disease BEFREE In conclusion, (1) the presence of NIDDM in the proband appears to be associated in siblings with more profound lipid and lipoprotein changes (especially low HDL cholesterol and high total triglycerides) than a history of CHD in the proband, (2) a history of CHD in the proband is associated in children with apolipoprotein changes favouring atherosclerosis (low apolipoprotein A1, high apolipoprotein B, low apolipoprotein A1/B ratio). 2064632 1991
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.100 GeneticVariation disease BEFREE We studied the apolipoprotein A-I/C-III gene cluster polymorphism in 97 Saudi Arabians in relation to coronary artery disease. 1900041 1991
Entrez Id: 336
Gene Symbol: APOA2
APOA2
0.030 Biomarker disease BEFREE Children of parents with CHD differed from controls in total cholesterol and apolipoprotein A II concentrations. 1929512 1991