|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The interleukin-6 (IL-6) gene promoter G-174C polymorphism has been associated with insulin resistance, hypertension, and coronary artery disease; however, its relationship with plasma PAI-1 level has not yet been studied.
|
15831362 |
2005 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, beneficial pleiotropic effects of statins on coronary artery disease may be attributable, in part, to attenuation of overexpression of PAI-1 mediated by the 3'-UTR in syndromes of insulin resistance (such as the metabolic syndrome) and type 2 diabetes.
|
20299979 |
2010 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reduced fibrinolytic capacity due to increased plasminogen activator inhibitor-1 (PAI-1) activity in plasma is a common finding in patients with coronary heart disease or venous thromboembolism, although its clinical significance is debated.
|
9569196 |
1998 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In linkage analysis there was no evidence for a linkage of the ACE or PAI-1 loci with CHD.
|
11427204 |
2001 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings provide a novel regulatory mechanism of miR-30c in regulating PAI-1/VN interactions and that may serve as a diagnostic biomarker of DM2 that is complicated with CHD.
|
31760103 |
2019 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PAI-1 gene locus 4G/5G polymorphism is associated with a family history of coronary artery disease.
|
9484978 |
1998 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G4G genotype is associated with myocardial infarction but not with stable coronary artery disease.
|
17721742 |
2008 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphism and synergism of angiotensin-converting enzyme (ACE) and plasminogen activator inhibitor-1 (PAI-1) genes in coronary artery disease.
|
25501306 |
2015 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An insertion or deletion (I/D) polymorphism in the angiotensin converting enzyme (ACE) gene and a 4/5-guanine tract polymorphism (4G/5G) in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene are associated with the plasma activities of these substances and with coronary heart disease.
|
9844142 |
1998 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to analyze the influence of the PAI-1 promoter 4G/5G genotype on PAI-1 levels in post-menopause women with coronary disease in comparison with healthy women in pre and postmenopausal status, and the influence of this genotype on variations in PAI-1 levels after hormone replacement therapy (HRT).
|
10235431 |
1999 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease.
|
7892190 |
1995 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery disease.
|
18307986 |
2008 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present data indicate that the 4G/4G genotype of the PAI-I gene polymorphism is an independent risk factor for coronary artery disease and that the additional presence of major cardiovascular risk factors accelerates the risk for this disease.
|
10494775 |
1999 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence suggested that the plasma levels of SERPINE1 modulate the risk of coronary artery disease; furthermore, that the 4G5G polymorphism affects the expression of the SERPINE1 gene.
|
20017074 |
2009 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There were no differences in prevalence of CHD or levels of blood pressure, serum lipids, or plasminogen activator inhibitor-1 (PAI-1) activity between the three ACE genotypes.
|
8521557 |
1995 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G gene polymorphism and coronary artery disease in the Chinese Han population: a meta-analysis.
|
22496752 |
2012 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
LHGDN |
[Plasminogen activator inhibitor-1 (PAI-1): pathogenetic role in coronary disease].
|
17975760 |
2007 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
[Association of plasminogen activator inhibitor-1 gene 4G/5G polymorphism and coronary heart disease in Chinese patients].
|
12362314 |
2002 |