Significant associations between microRNA-146ars2910164 polymorphism and CHD risk were observed in the total population, as well as in subgroup analysis.
Importantly, miR-146a expression is elevated in human atherosclerotic plaques, and polymorphisms in the <i>miR-146a</i> precursor have been associated with risk of coronary artery disease.
Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels.
We conducted a three-stage case-control study of CHD in Chinese to test our hypothesis by genotyping miR-196a2 rs11614913 and three other pre-miRNA SNPs (miR-146ars2910164, miR-149 rs2292832, and miR-499 rs3746444) in 1,324 CHD cases and 1,783 non-CHD controls.