Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease BEFREE Association of the HNF1A polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke. 28035729 2017
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 Biomarker disease CTD_human Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease BEFREE Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002). 22152955 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease BEFREE We investigated the association of the rs2259816 polymorphism in the HNF1A gene with the circulating level of C-reactive protein and the hazard of coronary artery disease in the LURIC Study cohort. 21062467 2010
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 AlteredExpression disease BEFREE Based on the recent genetic findings as well as delineation of the role of HNF1-alpha in regulating the expression of the CRP gene, it appears that this transcription factor may play a key role in linking metabolic and inflammatory pathways underlying the pathogenesis of coronary heart disease. 19280766 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease GWASCAT New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease GWASDB New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 GeneticVariation disease BEFREE The HNF1A Ser486Asn and/or Ile27Leu variants were also associated with increased risk of subclinical coronary atherosclerosis in Coronary Artery Risk Development in Young Adults and with incident coronary heart disease in Cardiovascular Health Study. 20031592 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 AlteredExpression disease BEFREE It is possible that the recent increase in CHD in the aboriginal people of northern Ontario is the result of the expression of diabetes susceptibility due to HNF1A S319 as a consequence of rapid changes in environment and lifestyle. 11286643 2001
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.470 Biomarker disease BEFREE Coronary heart disease was more common in MODY3 than in IDDM (16 vs 4.5%; p < 0.02) but less common than in the older NIDDM patients (33.3%; p < 0.02). 9562352 1998