Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.560 | AlteredExpression | disease | BEFREE | Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. | 31582804 | 2020 | ||||
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0.560 | AlteredExpression | disease | BEFREE | The loss of the Nell1 function leads to skeletal defects in the cranial vault and vertebral column, and overexpression of Nell1 causes craniosynostosis in mice. | 27662520 | 2017 | ||||
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0.560 | Biomarker | disease | BEFREE | We investigated the therapeutic effects of a craniosynostosis-associated molecule, NEL-like molecule-1 (NELL1; NEL [a protein strongly expressed in neural tissue encoding the epidermal growth factor-like domain]), on osteolysis induced by polyethylene (PE)-particle debris. | 22404332 | 2012 | ||||
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0.560 | Biomarker | disease | BEFREE | The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration. | 20647499 | 2010 | ||||
|
0.560 | AlteredExpression | disease | BEFREE | We previously reported the upregulation of NELL-1 in human craniosynostosis and the overexpression of Nell-1 in transgenic animals that induced premature suture closure associated with increased osteoblast differentiation. | 17042739 | 2007 | ||||
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0.560 | Biomarker | disease | CTD_human | Nell-1 overexpression induced calvarial overgrowth and resulted in premature suture closure in a rodent model. | 14672347 | 2003 | ||||
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0.560 | Biomarker | disease | RGD | In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. | 12235118 | 2002 | ||||
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0.560 | AlteredExpression | disease | BEFREE | In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. | 12235118 | 2002 | ||||
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0.560 | AlteredExpression | disease | LHGDN | In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. | 12235118 | 2002 |