Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 AlteredExpression disease BEFREE Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. 31582804 2020
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 AlteredExpression disease BEFREE The loss of the Nell1 function leads to skeletal defects in the cranial vault and vertebral column, and overexpression of Nell1 causes craniosynostosis in mice. 27662520 2017
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 Biomarker disease BEFREE We investigated the therapeutic effects of a craniosynostosis-associated molecule, NEL-like molecule-1 (NELL1; NEL [a protein strongly expressed in neural tissue encoding the epidermal growth factor-like domain]), on osteolysis induced by polyethylene (PE)-particle debris. 22404332 2012
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 Biomarker disease BEFREE The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration. 20647499 2010
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 AlteredExpression disease BEFREE We previously reported the upregulation of NELL-1 in human craniosynostosis and the overexpression of Nell-1 in transgenic animals that induced premature suture closure associated with increased osteoblast differentiation. 17042739 2007
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 Biomarker disease CTD_human Nell-1 overexpression induced calvarial overgrowth and resulted in premature suture closure in a rodent model. 14672347 2003
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 Biomarker disease RGD In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 AlteredExpression disease BEFREE In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
0.560 AlteredExpression disease LHGDN In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002