| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.500 | GeneticVariation | disease | GWASCAT | Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. | 26192919 | 2015 | ||||
|
0.500 | GeneticVariation | disease | BEFREE | The PTPN2 gene mutation in T1D patients play a direct role in the destruction of beta cells while in Crohn's disease patients, it modulates the innate immune responses. | 26734582 | 2015 | ||||
|
0.500 | GeneticVariation | disease | BEFREE | The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151. | 26928573 | 2016 | ||||
|
0.500 | GeneticVariation | disease | GWASCAT | Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. | 26974007 | 2016 | ||||
|
0.500 | AlteredExpression | disease | BEFREE | Non-coding single nucleotide polymorphisms that repress PTPN2 expression have been linked with the development of type 1 diabetes, rheumatoid arthritis and Crohn's disease. | 27658548 | 2017 | ||||
|
0.500 | GeneticVariation | disease | GWASCAT | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. | 28067908 | 2017 | ||||
|
0.500 | Biomarker | disease | BEFREE | We hypothesized earlier that Single Nucleotide Polymorphisms (SNPs) in the negative regulators <i>Protein Tyrosine Phosphatase Non-receptor type 2 and 22</i> (<i>PTPN2/22)</i> lead to a dysregulated immune response, susceptibility to environmental triggers, and continued apoptosis as seen in chronic inflammation in RA and CD. | 29423382 | 2018 | ||||
|
0.500 | AlteredExpression | disease | BEFREE | Gene expression in <i>PTPN2/22</i> in CD subjects was significantly decreased by 2 folds compared to healthy controls (<i>P</i>-values < 0.05). | 29456405 | 2018 |