Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 AlteredExpression disease BEFREE Gene expression in <i>PTPN2/22</i> in CD subjects was significantly decreased by 2 folds compared to healthy controls (<i>P</i>-values < 0.05). 29456405 2018
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 Biomarker disease BEFREE We hypothesized earlier that Single Nucleotide Polymorphisms (SNPs) in the negative regulators <i>Protein Tyrosine Phosphatase Non-receptor type 2 and 22</i> (<i>PTPN2/22)</i> lead to a dysregulated immune response, susceptibility to environmental triggers, and continued apoptosis as seen in chronic inflammation in RA and CD. 29423382 2018
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 AlteredExpression disease BEFREE Non-coding single nucleotide polymorphisms that repress PTPN2 expression have been linked with the development of type 1 diabetes, rheumatoid arthritis and Crohn's disease. 27658548 2017
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151. 26928573 2016
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease GWASCAT Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. 25489960 2015
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 Biomarker disease BEFREE Our data demonstrate that dysfunction of PTPN2 results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in human CD. 25492475 2015
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE The PTPN2 gene mutation in T1D patients play a direct role in the destruction of beta cells while in Crohn's disease patients, it modulates the innate immune responses. 26734582 2015
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. 25489960 2015
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE Though several polymorphisms have been identified in PTPN2, their roles in the incidence of UC and CD are conflicting. 24127071 2014
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 AlteredExpression disease BEFREE In stage 3 we studied the relationship between PTPN2 protein expression and mucosal inflammation and carried out in silico analyses to study the functional characteristics of the PTPN2 CD-associated SNPs. 23518806 2013
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE We identified a novel association between the genetic variant, rs1893217, located in intron 7 of the PTPN2 gene and CD. 22021207 2012
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 Biomarker disease BEFREE Recent studies associated variants within the gene loci, encoding protein tyrosine phosphatase nonreceptor type 2 (PTPN2), and autophagy genes, such as autophagy-related 16-like 1 (ATG16L1), with chronic inflammatory disorders, such as Crohn's disease (CD). 21987459 2012
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE These data identify an important functional role for PTPN2 as a protector of the intestinal epithelial barrier and provide clues as to how PTPN2 mutations may contribute to the pathophysiology of CD. 22671596 2012
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC. 22457781 2012
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 Biomarker disease BEFREE These results suggest that PTPN2 may have an important role in CD pathogenesis and may represent a potential diagnostic and therapeutic target for IBD. 22377701 2012
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population. 22426692 2012
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 AlteredExpression disease BEFREE Though samples from patients with active ulcerative colitis (UC) revealed more PTPN2 protein than non-IBD patients and patients with UC in remission, their PTPN2 expression was lower than in active CD. 21115548 2011
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated. 21830272 2011
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease BEFREE The SNPs tagging the TNFSF15, NKX2-3, ZNF365, and PTPN2 genes were associated with CD (P values ranging from 0.037 to 7×10(-6)). 21818367 2011
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 GeneticVariation disease GWASDB A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. 21298027 2011
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 Biomarker disease BEFREE Notable genes with VDR binding included IRF8, associated with MS, and PTPN2 associated with Crohn's disease and T1D. 20736230 2010
Entrez Id: 5771
Gene Symbol: PTPN2
PTPN2
0.500 Biomarker disease BEFREE In this sample, we were able to confirm an association between CD and PTPN2 (genotypic P = 0.019 and allelic P = 0.011), and phenotypic analysis showed an association of this SNP with late age at first diagnosis, inflammatory and penetrating CD behaviour, requirement of bowel resection and being a smoker at diagnosis. 20403149 2010